I've stayed in a lot of "affordable" hotels in San Francisco, and none can match my experience with Hotel Vertigo.
The room itself was well designed, comfortable, and clean. Everything was modern and updated, and the space provided was sufficient for both vacationing and getting some work done. The room has a work desk, TV, and even a mini fridge, helping drive down those expensive going-out-to-eat-for-every-meal costs. I'm a stickler for water pressure, and the standing shower provided the perfect amount. The room also had its own coffee machine, which is always appreciated.
The staff was welcoming at both check-in and check-out, offering helpful tips and services. The location of the building was quiet and clean, unlike other areas of the city.
All-in-all, Hotel Vertigo is a place I'd choose again and again when visiting SF.