Hotels in Seneca

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Next weekend
In two weeks

Where to stay in Seneca?

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (723 reviews)
Serene hotel within a 15-minute drive of Clemson University offers a seasonal outdoor pool, complimentary WiFi, parking, and breakfast. Toy Train Park and The Gauntlet attractions are nearby, with guests consistently praising the quiet atmosphere and attentive service.
The price is $80
$94 total
includes taxes & fees
Jul 26 - Jul 27
Quality Inn Seneca Clemson Area US-123

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (86 reviews)
Tucked between Lake Hartwell and Lake Keowee, these charming cabins offer serene patios and well-equipped kitchenettes. Just minutes from outdoor recreation areas and Cross Creek Plantation Golf, with free parking and cozy climate control for year-round comfort.
The price is $93
$146 total
includes taxes & fees
Aug 3 - Aug 4
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (757 reviews)
This Seneca motel offers easy access to Clemson University and Lake Keowee. Take a refreshing dip in the seasonal outdoor pool after exploring nearby Lake Hartwell. Free WiFi, parking, and daily on-the-go breakfast add exceptional value.
The price is $70
$77 total
includes taxes & fees
Jul 12 - Jul 13
Days Inn by Wyndham Seneca / Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
Unwind at this lakeside retreat with a poolside bar and seasonal outdoor pool just minutes from Clemson University. The 24-hour fitness center and hot tub provide recreation options while the restaurant and lounge offer on-site dining convenience.
The price is $109
$135 total
includes taxes & fees
Jul 6 - Jul 7
Lakeside Lodge Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (674 reviews)
Located within a 10-minute drive of Clemson University, this Seneca hotel offers a seasonal outdoor pool and free daily breakfast. Guests appreciate the helpful staff and clean rooms, while enjoying convenient access to local attractions.
The price is $97
$107 total
includes taxes & fees
Jul 9 - Jul 10
Best Western Seneca-Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (244 reviews)
Minutes from Clemson University and Lakes Keowee and Hartwell, this Seneca hotel offers free breakfast and parking. Refresh at the outdoor pool or fitness center after exploring nearby Golden Corner Plaza and Gignilliat Community Center.
The price is $129
$142 total
includes taxes & fees
Jul 5 - Jul 6
Fairfield Inn & Suites Seneca Clemson Univ Area

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (859 reviews)
This convenient Seneca hotel offers a complimentary morning meal, fitness center, and free parking just 5 minutes from campus. Guests praise the attentive staff, while Littlejohn Coliseum and Sloan Tennis Center are located nearby.
The price is $105
$115 total
includes taxes & fees
Jul 12 - Jul 13
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (726 reviews)
Just 5 minutes from Lake Keowee, this hotel offers a 24-hour fitness center and seasonal outdoor swimming. Enjoy complimentary breakfast, WiFi, and parking while staying close to Clemson University. Guests consistently praise the helpful staff and clean accommodations.
The price is $119
$131 total
includes taxes & fees
Jul 9 - Jul 10
Hampton Inn & Suites Seneca-Clemson Area

Carolina Inn Anderson Clemson Area

Carolina Inn Anderson Clemson Area
2.5 star property
Anderson
7.6 out of 10, Good, (16 reviews)
The price is $55
$67 total
includes taxes & fees
Jul 5 - Jul 6
Carolina Inn Anderson Clemson Area

Hampton Inn Hartwell

Hampton Inn Hartwell
2.5 star property
Hartwell
9.0 out of 10, Wonderful, (377 reviews)
Unwind at this welcoming Hartwell hotel near the botanical gardens. The outdoor pool offers refreshing relaxation while free breakfast and parking add value. Fitness enthusiasts will appreciate the workout center, and a friendly bar awaits for evening drinks.
The price is $115
$137 total
includes taxes & fees
Jul 11 - Jul 12
Hampton Inn Hartwell

The Point At Lake Hartwell

The Point At Lake Hartwell
3.0 star property
Townville
The price is $125
$139 total
includes taxes & fees
Jul 5 - Jul 6
The Point At Lake Hartwell

Econo Lodge Lavonia I-85

Econo Lodge Lavonia I-85
2.0 star property
Lavonia
5.8 out of 10, (80 reviews)
Dive into the seasonal outdoor pool at this Lavonia hotel before exploring nearby Lavonia Carnegie Library and City Park. Enjoy convenient perks including free WiFi, parking, and daily continental breakfast. Business travelers will appreciate the hotel's friendly atmosphere.
The price is $63
$77 total
includes taxes & fees
Jul 19 - Jul 20
Econo Lodge Lavonia I-85

Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (845 reviews)
The price is $65
$72 total
includes taxes & fees
Jul 12 - Jul 13
Baymont by Wyndham Easley/Greenville

Days Inn by Wyndham Easley/Greenville/Clemson Area

Days Inn by Wyndham Easley/Greenville/Clemson Area
2.0 star property
Easley
6.4 out of 10, (871 reviews)
Escape to this welcoming Days Inn where a seasonal outdoor pool refreshes after exploring nearby trails. Located close to Easley Recreation Center and Dollar Tree Plaza, the motel offers free breakfast, WiFi, and parking. Guests consistently praise the helpful staff and clean accommodations.
The price is $64
$71 total
includes taxes & fees
Jul 5 - Jul 6
Days Inn by Wyndham Easley/Greenville/Clemson Area

Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
Anderson
9.0 out of 10, Wonderful, (752 reviews)
This Anderson hotel offers quiet comfort with Garden Grille breakfast and a welcoming bar. After exploring nearby attractions, return to clean rooms with refrigerators and microwaves. Guests praise the helpful staff and free parking.
The price is $99
$110 total
includes taxes & fees
Jul 11 - Jul 12
Hilton Garden Inn Anderson

Super 8 by Wyndham Lavonia

Super 8 by Wyndham Lavonia
2.0 star property
Lavonia
6.8 out of 10, (515 reviews)
Wake up to complimentary breakfast at this peaceful Lavonia hotel, where guests praise the quiet atmosphere. Take a refreshing dip in the seasonal outdoor pool before exploring nearby Lavonia Water Works Lake, with free WiFi and parking for added convenience.
The price is $55
$69 total
includes taxes & fees
Jul 30 - Jul 31
Super 8 by Wyndham Lavonia

Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.6 out of 10, Exceptional, (10 reviews)
Experience cozy comfort in this well-appointed cottage featuring a full kitchen and washer/dryer. Just 5 minutes from Clemson University and Lake Hartwell, with free WiFi and parking. The balcony offers a perfect spot to unwind after exploring nearby South Carolina Botanical Gardens.
The price is $89
$238 total
includes taxes & fees
Jul 5 - Jul 6
Clemson Memorabilia House

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (3 reviews)
The price is $169
$271 total
includes taxes & fees
Jul 5 - Jul 6
Carolina Camp Cedar

Americas Best Value Inn Anderson, SC

Americas Best Value Inn Anderson, SC
2.0 star property
Anderson
6.2 out of 10, (173 reviews)
Wake up to a complimentary continental breakfast at this practical Anderson motel. Enjoy hiking trails nearby, plus free WiFi and parking. Anderson Civic Center and Mall are close, while Clemson University is just a short drive away.
The price is $55
$61 total
includes taxes & fees
Jul 6 - Jul 7
Americas Best Value Inn Anderson, SC

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.2 out of 10, Very Good, (1,003 reviews)
Walking distance from Clemson Station, this welcoming hotel sits just 5 minutes from the university campus. After a free breakfast, cool off in the seasonal outdoor pool or hit the 24-hour fitness center. Nearby attractions and quiet, comfortable rooms await.
The price is $95
$106 total
includes taxes & fees
Jul 5 - Jul 6
Best Western Plus Clemson Hotel & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Get last-minute hotel deals in Seneca and save more

Sign in to unlock great savings.
Showing deals for:Jul 4 - Jul 5
Showing deals for:Jul 5 - Jul 6
Showing deals for:Jul 10 - Jul 12

Check out pet-friendly hotels in Seneca

You may also like hotels with pools in Seneca

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

When is the best time to visit Seneca?

Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveler single night rates
View properties in July
Currently viewing crowd sizes and weather for July.
Typical weather for Seneca
July
High 32°C / low 21°C. Sunny most days.
View properties in July
32°
weather_sun
July, no crowd data, average high temperature 32 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
31°
weather_sun
August, no crowd data, average high temperature 31 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
28°
weather_sun
September, no crowd data, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
23°
weather_sun
October, no crowd data, average high temperature 23 degrees Celsius, average low temperature 12 degrees Celsius. Sunny most days.
12°
17°
weather_sun
November, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
12°
weather_sun
December, no crowd data, average high temperature 12 degrees Celsius, average low temperature 4 degrees Celsius. Sunny most days.
10°
weather_partly_sunny
January, no crowd data, average high temperature 10 degrees Celsius, average low temperature 1 degrees Celsius. Partly sunny.
13°
weather_partly_sunny
February, no crowd data, average high temperature 13 degrees Celsius, average low temperature 3 degrees Celsius. Partly sunny.
17°
weather_sun
March, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
22°
weather_sun
April, no crowd data, average high temperature 22 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
10°
26°
weather_sun
May, no crowd data, average high temperature 26 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
15°
31°
weather_sun
June, no crowd data, average high temperature 31 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
19°
Monthly weather averages (˚C)

Top neighborhoods in Seneca

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colorful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The neighborhood trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This neighborhood is all about authentic lakeside living without commercial distractions. Most travelers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy neighborhood in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The neighborhood gets incredibly quiet after dark—ideal for travelers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

A calm lake with mountains in the background.

Check out reviews of Seneca hotels guests love

Frequently asked questions

What accommodations do travelers like in Seneca?
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Quality Inn Seneca Clemson Area US-123 and Tru by Hilton Seneca Clemson are a few accommodations you might want to consider that'll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 207 vacation homes. In addition, there are 20 apartments and 12 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.