Hotels in Sanderson
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The Blanche
The Blanche
2.0 star property
Lake City
9.2 out of 10, Wonderful, (163)
9.2/10
Wonderful
(163)
- Discover Lake City charm with free WiFi and premium bedding at this central hotel.
The price is $165
$165
$186 total
includes taxes & fees
Dec 29 - Dec 30
Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
- Rest easy by Lake City's attractions with a comfy, business-ready stay and pool.
The price is $114
$114
$128 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Motel 6 – Lake City, Fl – Medical Center
Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.2 out of 10, Very Good, (83)
8.2/10
Very Good
(83)
- Central Florida stopover with comfortable rooms near I-75 and Medical Center.
The price is $61
$61
$69 total
includes taxes & fees
Dec 28 - Dec 29
Travelodge Suites by Wyndham MacClenny/I-10
Travelodge Suites by Wyndham MacClenny/I-10
2.0 star property
MacClenny
5.6 out of 10, (237)
5.6/10
(237)
- Affordable roadside convenience with room service along the I-10 corridor.
The price is $64
$64
$70 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Holiday Inn Express & Suites Macclenny by IHG
Holiday Inn Express & Suites Macclenny by IHG
2.5 star property
MacClenny
9.2 out of 10, Wonderful, (285)
9.2/10
Wonderful
(285)
- Explore scenic MacClenny with easy access to Heritage Park Village and I-10.
The price is $72
$72
$79 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1000)
8.6/10
Excellent
(1000)
- Fitness-focused retreat with quick interstate access and helpful hotel staff.
The price is $99
$99
$111 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Suites Lake City
Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1000)
9.6/10
Exceptional
(1000)
- Stylish hotel with outdoor pool in Lake City near Cinema 90, complete with fitness center.
The price is $107
$107
$120 total
includes taxes & fees
Jan 11 - Jan 12, 2026
La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1020)
8.8/10
Excellent
(1020)
- Take a dip in this Lake City hotel's indoor pool at any hour of the day or night.
The price is $94
$94
$105 total
includes taxes & fees
Dec 25 - Dec 26
Tru by Hilton Lake City
Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1010)
9.2/10
Wonderful
(1010)
- Convenient stay with fitness center and outdoor pool near Lake City attractions.
The price is $100
$100
$113 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Regal Inn
Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (543)
8.6/10
Excellent
(543)
- Experience comfort just minutes away from Lake City attractions and dining options.
The price is $62
$62
$70 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Red Roof Inn Baldwin
Red Roof Inn Baldwin
2.0 star property
Westside
7.8 out of 10, Good, (574)
7.8/10
Good
(574)
- Quiet Jacksonville escape near city attractions with free breakfast each day.
The price is $92
$92
$105 total
includes taxes & fees
Dec 25 - Dec 26
Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (179)
9.6/10
Exceptional
(179)
- Relax in spacious rooms at this Lake City hotel close to cinema and shopping.
The price is $107
$107
$120 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Motel 6 Macclenny, FL
Motel 6 Macclenny, FL
2.0 star property
MacClenny
7.4 out of 10, Good, (477)
7.4/10
Good
(477)
- Restful lodging near Jacksonville with attentive service and convenient amenities.
The price is $66
$66
$73 total
includes taxes & fees
Dec 25 - Dec 26
Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (167)
9.0/10
Wonderful
(167)
- A modern retreat near Lake City Mall with an indoor pool and free breakfast.
The price is $89
$89
$100 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1002)
5.0/10
(1002)
- Unwind at this Lake City hotel with an outdoor pool, hot tub, and gym access.
The price is $58
$58
$65 total
includes taxes & fees
Dec 25 - Dec 26
Econo Lodge Lake City-North
Econo Lodge Lake City-North
2.0 star property
Lake City
6.8 out of 10, (400)
6.8/10
(400)
- Dive into comfort at this Lake City hotel with free breakfast and outdoor pool.
The price is $73
$73
$82 total
includes taxes & fees
Dec 25 - Dec 26
Hampton Inn & Suites MacClenny I-10
Hampton Inn & Suites MacClenny I-10
2.5 star property
MacClenny
9.4 out of 10, Exceptional, (747)
9.4/10
Exceptional
(747)
- Wake up refreshed just off I-10 in MacClenny with free breakfast and parking.
The price is $93
$93
$103 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.2 out of 10, Good, (664)
7.2/10
Good
(664)
- Cool Lake City getaway with free perks and outdoor pool near local attractions.
The price is $66
$66
$75 total
includes taxes & fees
Dec 28 - Dec 29
Homestay Inn & Suites
Homestay Inn & Suites
2.5 star property
MacClenny
The price is $45
$45
$73 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (734)
9.4/10
Exceptional
(734)
- Serene lakeside hotel with pool and 24-hour fitness center for peaceful stays.
The price is $122
$122
$138 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Budget hotels in Sanderson and vicinity
7.8 out of 10, Good, (757)
7.8/10
Good
(757)
The price is $51
$51
$57 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Motel 6 – Lake City, Fl – Medical Center
Motel 6 – Lake City, Fl – Medical Center2.0 star property
Lake City
8.2 out of 10, Very Good, (83)
8.2/10
Very Good
(83)
The price is $61
$61
$69 total
includes taxes & fees
Dec 28 - Dec 29
7.8 out of 10, Good, (133)
7.8/10
Good
(133)
The price is $61
$61
$69 total
includes taxes & fees
Dec 28 - Dec 29
7.4 out of 10, Good, (638)
7.4/10
Good
(638)
The price is $63
$63
$69 total
includes taxes & fees
Dec 30 - Dec 31
7.6 out of 10, Good, (1001)
7.6/10
Good
(1001)
The price is $63
$63
$71 total
includes taxes & fees
Dec 28 - Dec 29
7.4 out of 10, Good, (581)
7.4/10
Good
(581)
The price is $65
$65
$73 total
includes taxes & fees
Dec 25 - Dec 26
7.2 out of 10, Good, (664)
7.2/10
Good
(664)
The price is $66
$66
$75 total
includes taxes & fees
Dec 28 - Dec 29
7.4 out of 10, Good, (477)
7.4/10
Good
(477)
The price is $66
$66
$73 total
includes taxes & fees
Dec 25 - Dec 26
7.8 out of 10, Good, (953)
7.8/10
Good
(953)
The price is $72
$72
$81 total
includes taxes & fees
Jan 22 - Jan 23, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $71
$71
$80 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn Express & Suites Macclenny by IHG
Holiday Inn Express & Suites Macclenny by IHG2.5 star property
MacClenny
9.2 out of 10, Wonderful, (285)
9.2/10
Wonderful
(285)
The price is $72
$72
$79 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.0 out of 10, Wonderful, (167)
9.0/10
Wonderful
(167)
The price is $89
$89
$100 total
includes taxes & fees
Jan 11 - Jan 12, 2026
7.8 out of 10, Good, (574)
7.8/10
Good
(574)
The price is $92
$92
$105 total
includes taxes & fees
Dec 25 - Dec 26
9.2 out of 10, Wonderful, (1021)
9.2/10
Wonderful
(1021)
The price is $87
$87
$98 total
includes taxes & fees
Dec 28 - Dec 29
9.4 out of 10, Exceptional, (747)
9.4/10
Exceptional
(747)
The price is $93
$93
$103 total
includes taxes & fees
Dec 31 - Jan 1, 2026
La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City2.5 star property
Lake City
8.8 out of 10, Excellent, (1020)
8.8/10
Excellent
(1020)
The price is $94
$94
$105 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHG3.0 star property
Lake City
8.6 out of 10, Excellent, (1000)
8.6/10
Excellent
(1000)
The price is $99
$99
$111 total
includes taxes & fees
Jan 18 - Jan 19, 2026
9.2 out of 10, Wonderful, (1010)
9.2/10
Wonderful
(1010)
The price is $100
$100
$113 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.6 out of 10, Exceptional, (179)
9.6/10
Exceptional
(179)
The price is $107
$107
$120 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Sanderson
Pet friendly
Family friendly
Check out reviews of Sanderson hotels guests love
Motel 6 – Lake City, Fl – Medical Center
10/10 Excellent
"The staff was very helpful and friendly"
Hampton Inn & Suites MacClenny I-10
10/10 Excellent
"Nice,clean hotele.Dog friendly!"
La Quinta Inn & Suite by Wyndham Lake City
10/10 Excellent
"All staff we had contact with were friendly and efficient. The man at the check-in desk answered questions we had regarding area dining. We appreciated his comments. The lady who stocked the breakfast buffet was also very nice."
Best Western Plus Lake City
10/10 Excellent
"Wonderful! Our room was clean and very comfortable and spacious. Staff have been kind and helpful. "
Holiday Inn Express & Suites Macclenny by IHG
10/10 Excellent
"Room is very clean. Friendly front desk and staff. Free breakfast."
Tru by Hilton Lake City
10/10 Excellent
"Clean room . Staff very polite and professional. Very quiet "
Comfort Suites Lake City
10/10 Excellent
"Great staff"
Baymont by Wyndham Lake City I-75
10/10 Excellent
"Friendly staff and very clean room"
Americas Best Value Inn Lake City
10/10 Excellent
"Room was clean,bed was very comfortable, bathroom spotless. Good air conditioning or heat. Impressed for the price. Only little draw back is the area seems a bit seedy but absolutely no issues. Would stay again. Staff very accommodating."
Frequently asked questions
What accommodations do travelers like in Sanderson?
Can I book a refundable hotel in Sanderson?
If you want the flexibility to change your plans to Sanderson, most hotels offer refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Sanderson be like during my vacation?
The warmest months in Sanderson are usually July and August with an average temp of 80°F. January and February are the chilliest months when the average temp is 59°F. The rainiest months are August and June.
Why should I book my Sanderson accommodation with Hotels.com?
There are plenty of reasons to book your Sanderson travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.