Hotels in Panacea

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Sep 7 - Sep 8
Tomorrow
Sep 8 - Sep 9
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Where to stay in Panacea?

A pink door with a window, set in a corrugated metal exterior with wooden trim.
A bedroom with a bed, a bench, a wooden wardrobe, and a wall with starfish and a framed picture.
A wooden bench in a natural setting with trees and a body of water in the background.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a sink. There are wooden shelves above the counter and a window with a view.

1. The Panacea Motel

The Panacea Motel
Panacea
$119
$133 total
includes taxes & fees
Sep 8 - Sep 9
The Panacea Motel
A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.
A hotel with a covered patio, outdoor seating, and a central pathway leading to the entrance.
A hotel lobby with a coffee bar, seating area, and a clock on the wall.
A modern hotel lobby with a sofa, armchairs, a desk, and a TV.

2. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
$111
$124 total
includes taxes & fees
Sep 22 - Sep 23
Best Western Wakulla Inn & Suites
A spacious indoor area with tiled flooring, multiple tables and chairs, a stone fireplace, and a glass door entrance.
A hotel room with a bed, a desk, a chair, a small table with a vase, a trash bin, and a wooden door.
A stone fireplace with a painting above it, wooden walls, a dining area with chairs, and a view of parked cars through large windows.

3. Wildwood Inn

Wildwood Inn
Crawfordville
$118
$135 total
includes taxes & fees
Oct 4 - Oct 5
Wildwood Inn
A spacious lobby with leather sofas, a coffee table, and a large window with arched frames.
A spacious dining area with multiple tables and chairs, large windows, and hanging chandeliers.
A spacious lobby with high ceilings, ornate ceiling decorations, and large windows.
A courtyard with a central fountain, surrounded by well-maintained hedges and trees.

4. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
$89
$100 total
includes taxes & fees
Sep 8 - Sep 9
The Lodge at Wakulla Springs
A covered patio with a table and chairs, a wooden ceiling fan, and a view of the surrounding greenery.
The Carrabelle Hotel with a white exterior, multiple balconies, and surrounded by tropical vegetation.
A yellow door with a window, a potted plant, a white wall-mounted light fixture, and a staircase with yellow curtains.
A bedroom with a wooden four-poster bed, a ceiling fan, a bookshelf, and a wall-mounted lamp.

5. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
$99
$109 total
includes taxes & fees
Sep 9 - Sep 10
The Old Carrabelle Hotel
A marina with boats docked, a small building, and a clear sky.
A spacious room with a pool table, a billiards table, and a dining area with chairs and a table.
A spacious room with a pool table, a round dining table with chairs, and large windows offering a view of a body of water.
A pool area with a table and chairs, a building with doors, and a palm tree.

6. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
$138
$153 total
includes taxes & fees
Oct 1 - Oct 2
The Moorings Hotel and Marina
A hotel room with two beds, a nightstand, a lamp, and a bathroom visible through an open door.
A motel with a single-story structure, a covered parking area, and a palm tree in front.
A hotel room with a large bed, two bedside tables, a desk with a chair, and a lamp.
A bathroom with a toilet, shower, and sink with a marble countertop.

7. Franklin Inn

Franklin Inn
Carrabelle
$104
$115 total
includes taxes & fees
Sep 8 - Sep 9
Franklin Inn
View all properties

Get last-minute hotel deals in Panacea and save more

Sign in to unlock great savings.
A pink door with a window, set in a corrugated metal exterior with wooden trim.
A bedroom with a bed, a bench, a wooden wardrobe, and a wall with starfish and a framed picture.
A wooden bench in a natural setting with trees and a body of water in the background.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a sink. There are wooden shelves above the counter and a window with a view.

The Panacea Motel

The Panacea Motel
Panacea
$138
per night
$308 total
includes taxes & fees
The Panacea Motel
A modern kitchen with white cabinets, stainless steel appliances, and a dining area with wooden chairs and a table.
A kitchen with a stainless steel refrigerator, wooden ceiling fan, and a dining area with a table and chairs.
A living room with a wooden ceiling, a television, a green armchair, a sofa, and a coffee table.
A modern kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a coffee maker.

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
Panacea
$157
per night
$602 total
includes taxes & fees
2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
A beach with wooden chairs and a table, overlooking the ocean.
A small, single-story building with large windows, a covered porch, and a picnic table.
A spacious living room with a large beige sectional sofa, a flat-screen TV mounted on the wall, and a ceiling fan.
A kitchen with a sink, countertop, and a view of the outside. There is a dining area with a table and chairs.

Waterfront Panacea Vacation Rental w/ Dock!

Waterfront Panacea Vacation Rental w/ Dock!
Panacea
$242
per night
$703 total
includes taxes & fees
Waterfront Panacea Vacation Rental w/ Dock!
A modern house with a patio, outdoor seating, and a grill.
A beach house with a white exterior, a yellow umbrella, and a sandy path leading to the entrance.
A spacious kitchen with wooden cabinets, a dining table, and a ceiling fan.
A dining area with a round wooden table, white upholstered chairs, a wicker pendant light, and a painting of a sailboat on the wall.

Casa Del Mare Beach to Bay on Alligator Point

Casa Del Mare Beach to Bay on Alligator Point
Panacea
$303
per night
$1,075 total
includes taxes & fees
Casa Del Mare Beach to Bay on Alligator Point
A modern kitchen with a central island, bar stools, and pendant lighting.
A modern kitchen with a wooden table, stainless steel appliances, and a ceiling light fixture.
A two-story house with a covered porch and a staircase leading to the upper level.
A wooden deck with a white railing, a covered porch area, and a view of palm trees and greenery.

Nature Lover's Paradise: Hike, Bike & Fish!

Nature Lover's Paradise: Hike, Bike & Fish!
Panacea
$193
per night
$832 total
includes taxes & fees
Nature Lover's Paradise: Hike, Bike & Fish!
Our prices for hotels in Panacea are cheapest in February
Price trends for hotels in Panacea
Pricing is based on two traveler single night rates
View properties in September
Typical weather for Panacea
September
High 30°C / low 23°C. Sunny most days.
View properties in September
30°
23°
27°
18°
22°
13°
19°
11°
17°
8°
19°
10°
22°
13°
25°
16°
29°
20°
31°
23°
32°
24°
32°
25°
Monthly weather averages (˚C)

Top landmarks in Panacea

Alligator Point Beach

8.8/10 (10 reviews)
When the beach is calling your name, you might want to head down to Alligator Point Beach, located 4.5 mi (7.2 km) from central Alligator Point. Enjoy the sunset by the shore at Wilson Beach.
See properties

Bald Point State Park

8.6/10 (20 reviews)
Bald Point State Park is 1.7 mi (2.7 km) from central Alligator Point, why not stop by during your stay.
See properties

Mashes Sand Beach

8.8/10 (3 reviews)
If being by the water is a major draw, Mashes Sand Beach is a spot you might want to check out, located 5.1 mi (8.2 km) from central Panacea. If you want to continue walking by the waves, head to Shell Point Beach, Wilson Beach, and Alligator Point Beach.
See properties

Wilson Beach

Whether you want to collect beach glass or watch the sunset, Wilson Beach is a spot you might want to check out, located 7.4 mi (11.9 km) from central Panacea. Enjoy the sunset by the shore at Alligator Point Beach.
See properties

beach near Alligator Point

When the beach is calling your name, you might want to head down to beach near Alligator Point, located 2.7 mi (4.4 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
See properties

beach near Summer Camp Beach

Whether you want to collect beach glass or watch the sunset, beach near Summer Camp Beach is a spot you might want to check out, located 10.3 mi (16.6 km) from central Panacea. If you want to continue walking by the waves, head to Wilson Beach and Alligator Point Beach.
See properties

Public Beach Access

Public Beach Access is 2.3 mi (3.7 km) from central Alligator Point, why not stop by during your stay. Want to stretch your legs some more? Head to Alligator Harbor Aquatic Preserve, located nearby.
See properties

beach near Sun N Sand Beaches

If you can't wait to get to the beach, you might enjoy a trip to beach near Sun N Sand Beaches located 0.6 mi (1 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Mashes Sand Beach.
See properties

Learn more about Panacea

Notable for its natural beauty, Panacea features attractions such as Mashes Sand Beach and Alligator Point Beach. This beachside city has something for everyone including seafood restaurants as well as sights like Bald Point State Park and Wilson Beach. All are within a secluded setting.

See all hotels in Panacea
A sunset over a calm body of water with silhouettes of birds flying and a distant tree line.

Check out reviews of Panacea hotels guests love

The Panacea Motel

The Panacea Motel

10/10 Excellent
"This was a cute little surprise right on the highway. We arrived pretty late, after 10 for sure but our room was ready and we were definitely ready for the place to rest."
Holly 1-night trip
Posted 9 days ago
The Panacea Motel

Frequently asked questions

What hotels do travelers like in Panacea?
Guests like The Panacea Motel.
Can I book a refundable accommodation in Panacea?
If you're looking for the flexibility to change your travel plans to Panacea, most accommodations offer refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Panacea if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, browse our selection of 177 vacation homes. In addition, there are 18 apartments and 10 condos.
What will the weather in Panacea be like during my visit?
July and August are typically the warmest months in Panacea when the average temp is 81°F. January and February are the coldest months when the average temperature is 58°F. August and July are the months with the most rain.
Why should I book my Panacea hotel through Hotels.com?
There are lots of reasons to book your Panacea trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring