Hotels in Defiance

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Next weekend
Jul 17 - Jul 19
In two weeks
Jul 24 - Jul 26

Where to stay in Defiance?

Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,005 reviews)
Tucked into Warrenton with friendly, helpful staff, this motel offers a peaceful retreat after exploring nearby attractions. Enjoy the indoor pool, free continental breakfast, WiFi and parking. Clean, comfortable rooms provide a quiet environment for business or leisure travelers.
The price is $82
$93 total
includes taxes & fees
Jul 27 - Jul 28
Baymont by Wyndham Warrenton
Exterior

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (545 reviews)
Unwind at this peaceful hotel featuring an indoor pool and fitness center. Start your day with free breakfast before exploring nearby Dyer Park and Veteran's Memorial. Enjoy free WiFi, complimentary parking, and the helpful staff that guests consistently praise.
The price is $119
$135 total
includes taxes & fees
Jul 26 - Jul 27
Holiday Inn Express Warrenton by IHG
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (1,009 reviews)
Escape to a quiet retreat with a free full breakfast to fuel your day. Explore nearby Cedar Lake Cellars, then return to clean, comfortable rooms. The fitness center keeps routines on track, while the helpful staff ensures a restful experience.
The price is $84
$95 total
includes taxes & fees
Jul 26 - Jul 27
Quality Inn Foristell
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.0 out of 10, Wonderful, (707 reviews)
Relax at this hotel near Washington Station, featuring an indoor pool, hot tub, and 24-hour fitness center. Enjoy complimentary breakfast, WiFi, and parking before exploring nearby South Point Bark Park or Optimist Park. Rooms include refrigerators and microwaves for added convenience.
The price is $129
$147 total
includes taxes & fees
Jul 12 - Jul 13
Best Western Plus Washington Hotel
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
7.8 out of 10, Good, (1,425 reviews)
Find unexpected tranquility at this Fenton hotel with dual pools. The quiet atmosphere, convenient location, and free breakfast earn top marks, while nearby Museum of Transportation offers unique exploration. Friendly staff and free parking add value.
The price is $94
$109 total
includes taxes & fees
Jul 12 - Jul 13
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
Wentzville
6.4 out of 10, (550 reviews)
The price is $70
$79 total
includes taxes & fees
Jul 12 - Jul 13
Economy Inn Wentzville
Room, Accessible | Desk, iron/ironing board, free WiFi, bed sheets

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
O'Fallon
7.0 out of 10, Good, (1,005 reviews)
Take a dip in the indoor pool at this inviting hotel near CarShield Field and Alligator Creek Aquatic Center. Enjoy free WiFi, parking, and on-the-go breakfast daily. Business travelers appreciate the convenient location and clean, comfortable rooms.
The price is $66
$78 total
includes taxes & fees
Jul 19 - Jul 20
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,012 reviews)
Escape to a peaceful haven minutes from shopping and entertainment. This hotel offers quiet rooms despite its freeway proximity, plus free breakfast, WiFi, and parking. After exploring nearby attractions, unwind in the indoor pool or fitness center while enjoying exceptional staff service.
The price is $110
$126 total
includes taxes & fees
Jul 26 - Jul 27
Drury Inn & Suites St. Louis St. Peters
Front of property - evening/night

Cedar Creek

Cedar Creek
3.0 star property
New Haven
9.0 out of 10, Wonderful, (271 reviews)
Surrounded by beautiful Cedar Creek Golf Course, this lodge offers outdoor enthusiasts a 9-hole course, pool, and 24-hour fitness center. Just minutes from 2nd Shift Brewery with tennis courts and helpful staff to enhance your countryside retreat.
The price is $161
$172 total
includes taxes & fees
Jul 28 - Jul 29
Cedar Creek
Indoor pool

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,015 reviews)
Near the excitement of Ameristar Casino, this welcoming hotel provides an indoor pool for swimming anytime. Enjoy a complimentary breakfast, free WiFi, and parking, while the 24-hour fitness center keeps your workout routine intact during travels.
The price is $98
$112 total
includes taxes & fees
Jul 19 - Jul 20
Hampton Inn St. Charles St. Peters
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,048 reviews)
This welcoming Sleep Inn provides complimentary breakfast, WiFi, and parking near Weldon Spring Interpretive Center. The indoor pool invites morning swims while the fitness center keeps workouts on track. Comfortable beds and attentive staff ensure a restful business trip.
The price is $84
$99 total
includes taxes & fees
Jul 19 - Jul 20
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (946 reviews)
Unwind at this O'Fallon retreat featuring an indoor pool and fitness center just minutes from St. Louis. With complimentary breakfast, WiFi, and parking, plus proximity to Weldon Spring and Golf Headquarters, guests consistently praise the attentive staff.
The price is $89
$105 total
includes taxes & fees
Jul 19 - Jul 20
Holiday Inn Express St. Louis West - O'Fallon by IHG
Lobby

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very Good, (390 reviews)
Find peaceful comfort at this hotel just 10 minutes from Six Flags St. Louis. Enjoy complimentary perks including buffet breakfast, WiFi, and parking. The clean rooms and helpful staff receive praise from travelers, with Al Foster Memorial Trail nearby.
The price is $104
$119 total
includes taxes & fees
Jul 13 - Jul 14
Quality Inn Near Six Flags St. Louis
Exterior

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,009 reviews)
Wake up to a riverside retreat minutes from Ameristar Casino. This hotel offers free breakfast, WiFi, and parking, plus an indoor pool for year-round relaxation. Guests praise the attentive staff and spotless rooms near Lewis & Clark Boathouse.
The price is $93
$106 total
includes taxes & fees
Aug 4 - Aug 5
Comfort Suites St Charles - St Louis
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,280 reviews)
Experience peaceful nights at this Fenton hotel despite its prime location near major roads. Free continental breakfast and parking enhance your stay, while the outdoor pool offers refreshment after exploring nearby Museum of Transportation and shopping areas.
The price is $89
$103 total
includes taxes & fees
Jul 12 - Jul 13
Wingate by Wyndham St. Louis/Fenton Route 66
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (722 reviews)
Wake up refreshed at this Wentzville hotel with a free breakfast before exploring nearby attractions. After visiting Vietnam Veterans Memorial, unwind in the indoor pool or fitness center. Helpful staff and free WiFi ensure a smooth business trip.
The price is $147
$168 total
includes taxes & fees
Jul 19 - Jul 20
Hampton Inn St. Louis Wentzville
Premium bedding, desk, iron/ironing board, free cribs/infant beds

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.2 out of 10, Very Good, (1,008 reviews)
Wake up to a serene stay and complimentary morning meal at this quiet St. Charles retreat. Just minutes from Ameristar Casino and Cave Spring Golf Center, this hotel offers free WiFi, parking, and clean rooms with attentive staff to ensure comfort.
The price is $85
$97 total
includes taxes & fees
Jul 12 - Jul 13
Super 8 by Wyndham St Charles
Lobby

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,011 reviews)
Close to Six Flags St. Louis, this welcoming hotel offers both outdoor and indoor pools, plus a hot tub for evening relaxation. Enjoy complimentary perks including WiFi, parking, and breakfast that guests rave about.
The price is $128
$150 total
includes taxes & fees
Jul 16 - Jul 17
Drury Inn & Suites Southwest St. Louis
Iron/ironing board, free WiFi, bed sheets, alarm clocks

Americas Best Inn - Eureka

Americas Best Inn - Eureka
2.5 star property
Eureka
6.4 out of 10, (148 reviews)
The price is $73
$85 total
includes taxes & fees
Jul 20 - Jul 21
Americas Best Inn - Eureka
Free daily buffet breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (376 reviews)
The price is $95
$110 total
includes taxes & fees
Jul 12 - Jul 13
Best Western Plus Fenton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:Jul 17 - Jul 19
House (1 Bedroom) | Interior
The Reubling House - Modern-rustic Cabin!

The Reubling House - Modern-rustic Cabin!

The Reubling House - Modern-rustic Cabin!
3.0 star property
Defiance
10.0 out of 10, Exceptional, (1 review)
The price is $242
per night
$707 total
includes taxes & fees
The Reubling House - Modern-rustic Cabin!

Top landmarks in Defiance

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.
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Learn more about Defiance

Defiance is well-known for its attractions such as Chandler Hill Vineyards and Sugar Creek Winery.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Check out reviews of Defiance hotels guests love

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

8/10 Good
"Great staff whoever we encountered with ; hot continental breakfast ; pool was great ; facility shows “wears and tears” but for the buck it is still a god place to stay - clean rooms - rated 4 because I am particular with beds that tend to “shake “ when sleeping with someone and it wakes me up "
Adela Y 2-night trip
Posted 1 hour ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Frequently asked questions

What hotels do travelers recommend in Defiance?
Guests like The Wildwood Hotel and Sleep Inn & Suites O'Fallon MO - Technology Drive.
Can I book refundable accommodations in Defiance?
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.