Hotels in Florida Keys Scenic Highway
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Amoray Dive Resort
Amoray Dive Resort
2.0 star property
Key Largo
9.2 out of 10, Wonderful, (1008)
9.2/10
Wonderful
(1008)
- Coastal paradise near pristine John Pennekamp State Park awaits water enthusiasts.
The price is $157
$157
$204 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Azul del Mar
Azul del Mar
3.5 star property
Key Largo
9.0 out of 10, Wonderful, (802)
9.0/10
Wonderful
(802)
The price is $219
$219
$246 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Reefhouse Resort & Marina
Reefhouse Resort & Marina
3.5 star property
Key Largo
9.2 out of 10, Wonderful, (1331)
9.2/10
Wonderful
(1331)
- Unwind by a private beach minutes from John Pennekamp Coral Reef State Park.
The price is $249
$249
$320 total
includes taxes & fees
Dec 23 - Dec 24
Hampton Inn Key Largo Manatee Bay
Hampton Inn Key Largo Manatee Bay
2.5 star property
Key Largo
8.8 out of 10, Excellent, (1008)
8.8/10
Excellent
(1008)
- Seaside escape with a private beach and pool, minutes from Coral Reef State Park.
The price is $175
$175
$197 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Largo Resort
Largo Resort
3.0 star property
Key Largo
9.4 out of 10, Exceptional, (295)
9.4/10
Exceptional
(295)
- Palm-lined paradise minutes from the coral reef state park for a serene escape.
The price is $306
$306
$411 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Dolphin Point Villas
Dolphin Point Villas
3.5 star property
Key Largo
9.6 out of 10, Exceptional, (471)
9.6/10
Exceptional
(471)
- Beachfront escape with a private shore and nearby coral reef adventures.
The price is $239
$239
$297 total
includes taxes & fees
Dec 23 - Dec 24
Sunset Cove Beach Resort
Sunset Cove Beach Resort
2.5 star property
Key Largo
9.0 out of 10, Wonderful, (1002)
9.0/10
Wonderful
(1002)
The price is $221
$221
$249 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Pelican Key Largo Cottages
The Pelican Key Largo Cottages
2.0 star property
Key Largo
9.0 out of 10, Wonderful, (1004)
9.0/10
Wonderful
(1004)
- Coastal cottages with private marina and water adventures minutes from Key Largo's attractions.
The price is $147
$147
$165 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
- Beachside elegance on Key Largo with cabanas and marina access, plus 3 restaurants.
The price is $343
$343
$441 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Drop Anchor
Drop Anchor
3.0 star property
Islamorada
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
- Unwind at this oceanfront Art Deco gem with free kayaking and bicycles.
The price is $153
$153
$208 total
includes taxes & fees
Dec 24 - Dec 25
Chesapeake Beach Resort
Chesapeake Beach Resort
3.5 star property
Matecumbe
9.2 out of 10, Wonderful, (1601)
9.2/10
Wonderful
(1601)
- Escape to a peaceful ocean retreat with breathtaking sunset views in Islamorada.
The price is $189
$189
$269 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Cheeca Lodge & Spa
Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1278)
9.2/10
Wonderful
(1278)
The price is $399
$399
$522 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Breezy Palms Resort
Breezy Palms Resort
2.5 star property
Matecumbe
8.8 out of 10, Excellent, (589)
8.8/10
Excellent
(589)
- Coastal hideaway with marina access just steps from Breezy Palms Beach.
The price is $178
$178
$216 total
includes taxes & fees
Dec 23 - Dec 24
Bayside Villas by Islander Resort
Bayside Villas by Islander Resort
3.5 star property
Matecumbe
8.8 out of 10, Excellent, (401)
8.8/10
Excellent
(401)
The price is $314
$314
$421 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Sands of Islamorada
Sands of Islamorada
2.5 star property
Matecumbe
8.8 out of 10, Excellent, (392)
8.8/10
Excellent
(392)
The price is $181
$181
$217 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Lime Tree Bay Resort
Lime Tree Bay Resort
3.5 star property
Long Key
9.2 out of 10, Wonderful, (1108)
9.2/10
Wonderful
(1108)
- Beachfront escape with tennis, kayaking, and multiple pools along Florida's scenic Keys.
The price is $149
$149
$213 total
includes taxes & fees
Dec 23 - Dec 24
Edgewater Lodge
Edgewater Lodge
2.5 star property
Long Key
8.6 out of 10, Excellent, (801)
8.6/10
Excellent
(801)
- Oceanfront retreat with marina access and kayaking in Long Key, Florida.
The price is $269
$269
$303 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Rainbow Bend Resort
Rainbow Bend Resort
2.5 star property
Marathon
8.2 out of 10, Very Good, (786)
8.2/10
Very Good
(786)
- Enjoy the private Florida Keys beach and pool at an oceanfront hideaway in Marathon.
The price is $113
$113
$172 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Kingsail Resort
Kingsail Resort
2.0 star property
Marathon
8.6 out of 10, Excellent, (1044)
8.6/10
Excellent
(1044)
- Serene waterfront motel with marina access and a short drive to Sombrero Beach.
The price is $162
$162
$182 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Captain Pips Marina & Hideaway
Captain Pips Marina & Hideaway
3.0 star property
Marathon
9.0 out of 10, Wonderful, (1002)
9.0/10
Wonderful
(1002)
- Marina-side escape with outdoor pool and free bicycles near Sombrero Beach.
The price is $134
$134
$179 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Florida Keys Scenic Highway, FL
Showing deals for:Jan 2 - Jan 4
Image gallery for Drop Anchor
Drop Anchor
3.0 star property
Islamorada
8.8/10Excellent (1,000 reviews)
Member Price available
$320 nightly
Price is $791
$791
Total with taxes and fees
Total with taxes and fees
Image gallery for Lime Tree Bay Resort
VIP Access
Lime Tree Bay Resort
3.5 star property
Long Key
9.2/10Wonderful (1,108 reviews)
Member Price available
$299 nightly
Price is $763
$763
Total with taxes and fees
Total with taxes and fees
Image gallery for Bayside Villas by Islander Resort
Bayside Villas by Islander Resort
3.5 star property
Islamorada
8.8/10Excellent (401 reviews)
9% off
$540 nightly
Price is $1,350
$1,350
Total with taxes and fees
Total with taxes and fees
Image gallery for Ibis Bay Beach Resort
Ibis Bay Beach Resort
2.5 star property
Key West
8.2/10Very Good (2,017 reviews)
Member Price available
$434 nightly
Price is $1,031
$1,031
Total with taxes and fees
Total with taxes and fees
Image gallery for Breezy Palms Resort
Breezy Palms Resort
2.5 star property
Islamorada
8.8/10Excellent (589 reviews)
Member Price available
$291 nightly
Price is $759
$759
Total with taxes and fees
Total with taxes and fees
Image gallery for The Pelican Key Largo Cottages
The Pelican Key Largo Cottages
2.0 star property
Key Largo
9.0/10Wonderful (1,004 reviews)
15% off
$369 nightly
Price is $829
$829
Total with taxes and fees
Total with taxes and fees
Check out pet-friendly hotels in Florida Keys Scenic Highway
9.2 out of 10, Wonderful, (1331)
9.2/10
Wonderful
(1331)
The price is $249
$249
$320 total
includes taxes & fees
Dec 23 - Dec 24
8.8 out of 10, Excellent, (1008)
8.8/10
Excellent
(1008)
The price is $175
$175
$197 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.0 out of 10, Wonderful, (1002)
9.0/10
Wonderful
(1002)
The price is $221
$221
$249 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
The price is $343
$343
$441 total
includes taxes & fees
Jan 19 - Jan 20, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $153
$153
$208 total
includes taxes & fees
Dec 24 - Dec 25
9.2 out of 10, Wonderful, (1601)
9.2/10
Wonderful
(1601)
The price is $189
$189
$269 total
includes taxes & fees
Jan 6 - Jan 7, 2026
8.8 out of 10, Excellent, (392)
8.8/10
Excellent
(392)
The price is $181
$181
$217 total
includes taxes & fees
Jan 5 - Jan 6, 2026
9.2 out of 10, Wonderful, (1108)
9.2/10
Wonderful
(1108)
The price is $149
$149
$213 total
includes taxes & fees
Dec 23 - Dec 24
8.6 out of 10, Excellent, (801)
8.6/10
Excellent
(801)
The price is $269
$269
$303 total
includes taxes & fees
Jan 5 - Jan 6, 2026
8.2 out of 10, Very Good, (786)
8.2/10
Very Good
(786)
The price is $113
$113
$172 total
includes taxes & fees
Jan 8 - Jan 9, 2026
You may also like hotels with pools in Florida Keys Scenic Highway
9.2 out of 10, Wonderful, (1008)
9.2/10
Wonderful
(1008)
The price is $157
$157
$204 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.2 out of 10, Wonderful, (1331)
9.2/10
Wonderful
(1331)
The price is $249
$249
$320 total
includes taxes & fees
Dec 23 - Dec 24
8.8 out of 10, Excellent, (1008)
8.8/10
Excellent
(1008)
The price is $175
$175
$197 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.4 out of 10, Exceptional, (295)
9.4/10
Exceptional
(295)
The price is $306
$306
$411 total
includes taxes & fees
Jan 14 - Jan 15, 2026
9.6 out of 10, Exceptional, (471)
9.6/10
Exceptional
(471)
The price is $239
$239
$297 total
includes taxes & fees
Dec 23 - Dec 24
Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
The price is $343
$343
$441 total
includes taxes & fees
Jan 19 - Jan 20, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $153
$153
$208 total
includes taxes & fees
Dec 24 - Dec 25
9.2 out of 10, Wonderful, (1601)
9.2/10
Wonderful
(1601)
The price is $189
$189
$269 total
includes taxes & fees
Jan 6 - Jan 7, 2026
8.8 out of 10, Excellent, (589)
8.8/10
Excellent
(589)
The price is $178
$178
$216 total
includes taxes & fees
Dec 23 - Dec 24
8.8 out of 10, Excellent, (392)
8.8/10
Excellent
(392)
The price is $181
$181
$217 total
includes taxes & fees
Jan 5 - Jan 6, 2026
You can also stay at family-friendly hotels in Florida Keys Scenic Highway
9.2 out of 10, Wonderful, (1008)
9.2/10
Wonderful
(1008)
The price is $157
$157
$204 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.2 out of 10, Wonderful, (1331)
9.2/10
Wonderful
(1331)
The price is $249
$249
$320 total
includes taxes & fees
Dec 23 - Dec 24
8.8 out of 10, Excellent, (1008)
8.8/10
Excellent
(1008)
The price is $175
$175
$197 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.4 out of 10, Exceptional, (295)
9.4/10
Exceptional
(295)
The price is $306
$306
$411 total
includes taxes & fees
Jan 14 - Jan 15, 2026
9.6 out of 10, Exceptional, (471)
9.6/10
Exceptional
(471)
The price is $239
$239
$297 total
includes taxes & fees
Dec 23 - Dec 24
9.0 out of 10, Wonderful, (1004)
9.0/10
Wonderful
(1004)
The price is $147
$147
$165 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.2 out of 10, Wonderful, (1278)
9.2/10
Wonderful
(1278)
The price is $399
$399
$522 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.2 out of 10, Wonderful, (1108)
9.2/10
Wonderful
(1108)
The price is $149
$149
$213 total
includes taxes & fees
Dec 23 - Dec 24
8.2 out of 10, Very Good, (786)
8.2/10
Very Good
(786)
The price is $113
$113
$172 total
includes taxes & fees
Jan 8 - Jan 9, 2026
8.2 out of 10, Very Good, (2017)
8.2/10
Very Good
(2017)
The price is $229
$229
$285 total
includes taxes & fees
Dec 23 - Dec 24
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Florida Keys Scenic Highway
Apart hotel
Family friendly
Ocean view
Pet friendly
Resort
Condo
Apartment
Learn more about Florida Keys Scenic Highway
Florida Keys Scenic Highway is well-known for its attractions such as Duval Street and Curry Hammock State Park.
Check out reviews of Florida Keys Scenic Highway hotels guests love
Beachside Resort & Residences
10/10 Excellent
"Room was clean and in good shape"
DoubleTree Resort by Hilton Grand Key - Key West
10/10 Excellent
"Everything was good "
Southernmost Beach Resort and Guesthouses
10/10 Excellent
"Great Stay!"
Havana Cabana at Key West
10/10 Excellent
"Enjoyed stay, friendly staff and good shuttle bus"
Margaritaville Beach House Key West
10/10 Excellent
"VERY GOOD"
Hyatt Vacation Club at Windward Pointe, Key West
10/10 Excellent
"This is a great place to stay for family! The balcony was amazing! "
Hilton Garden Inn Key West / The Keys Collection
10/10 Excellent
"The front desk staff was amazing. The hotel is clean and in a wonderful location. They offer a free shuttle to the main area near Duval Street which is super convenient. We would definitely stay here again.
Oh and we were here celebrating my birthday and they left us a bottle of champagne and a cute card in our room, it totally made my day. "
Chesapeake Beach Resort
10/10 Excellent
"The breakfasts are great "
Blue Flamingo Resort Key West
10/10 Excellent
"This is the excellent hotel. The best most impressive hotel stay I have ever been to. It’s top clean. Wifi is super fast. Lots of charging outlet. Bath is super clean and shining. Resort has a lot of fun. "
Frequently asked questions
Why should I book my Florida Keys Scenic Highway accommodation with Hotels.com?
There are plenty of reasons to book your Florida Keys Scenic Highway travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.