Hotels in Sanctuary
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Where to stay in Sanctuary?
Tween Waters Island Resort & Spa
Tween Waters Island Resort & Spa3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1000)
8.6/10
Excellent
(1000)
The price is $339
$339
$413 total
includes taxes & fees
Dec 25 - Dec 26
9.4 out of 10, Exceptional, (1123)
9.4/10
Exceptional
(1123)
The price is $259
$259
$289 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Off the Charts Inn & Out Island Resort
Off the Charts Inn & Out Island Resort2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (144)
9.6/10
Exceptional
(144)
The price is $201
$201
$257 total
includes taxes & fees
Dec 30 - Dec 31
10.0 out of 10, Exceptional, (15)
10/10
Exceptional
(15)
The price is $409
$409
$456 total
includes taxes & fees
Dec 26 - Dec 27
8.4 out of 10, Very Good, (1003)
8.4/10
Very Good
(1003)
The price is $439
$439
$598 total
includes taxes & fees
Jan 4 - Jan 5, 2026
8.8 out of 10, Excellent, (290)
8.8/10
Excellent
(290)
The price is $519
$519
$579 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sanibel Island Beach Resort
Sanibel Island Beach Resort3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1481)
9.2/10
Wonderful
(1481)
The price is $259
$259
$314 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Sundial Beach Resort & Spa
Sundial Beach Resort & Spa5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2584)
8.6/10
Excellent
(2584)
The price is $386
$386
$485 total
includes taxes & fees
Jan 12 - Jan 13, 2026
9.0 out of 10, Wonderful, (1000)
9.0/10
Wonderful
(1000)
The price is $353
$353
$452 total
includes taxes & fees
Jan 7 - Jan 8, 2026
10.0 out of 10, Exceptional, (8)
10/10
Exceptional
(8)
The price is $356
$356
$638 total
includes taxes & fees
Dec 25 - Dec 26
Marriott Sanibel Harbour Resort & Spa
Marriott Sanibel Harbour Resort & Spa4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very Good, (1003)
8.4/10
Very Good
(1003)
The price is $319
$319
$381 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.6 out of 10, Exceptional, (392)
9.6/10
Exceptional
(392)
The price is $224
$224
$250 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Westin Cape Coral Resort At Marina Village
The Westin Cape Coral Resort At Marina Village4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1004)
9.0/10
Wonderful
(1004)
The price is $201
$201
$265 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Residence Inn by Marriott Fort Myers Sanibel
Residence Inn by Marriott Fort Myers Sanibel3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1004)
8.6/10
Excellent
(1004)
The price is $135
$135
$151 total
includes taxes & fees
Jan 4 - Jan 5, 2026
8.8 out of 10, Excellent, (268)
8.8/10
Excellent
(268)
The price is $125
$125
$215 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.4 out of 10, Exceptional, (322)
9.4/10
Exceptional
(322)
The price is $175
$175
$195 total
includes taxes & fees
Dec 27 - Dec 28
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway3.0 star property
19.9 km from Sanctuary
8.0 out of 10, Very Good, (1002)
8.0/10
Very Good
(1002)
The price is $131
$131
$146 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Pink Shell Beach Resort and Marina
Pink Shell Beach Resort and Marina4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1202)
9.4/10
Exceptional
(1202)
The price is $224
$224
$316 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.6 out of 10, Exceptional, (213)
9.6/10
Exceptional
(213)
The price is $75
$75
$151 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
The price is $176
$176
$196 total
includes taxes & fees
Dec 26 - Dec 27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
When is the best time to visit Sanibel?
When is the best time to visit Sanibel?Our prices for hotels in Sanibel are cheapest in July
When is the best time to visit Sanibel?
When is the best time to visit Sanibel?
Our prices for hotels in Sanibel are cheapest in July
Price trends for hotels in Sanibel
Pricing is based on two traveler single night rates
Currently viewing crowd sizes and weather for December.
Typical weather for Sanibel
December
Low crowds
High 23°C / low 18°C. Sunny most days.
View properties in December 23°
December, Low crowds, average high temperature 23 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
21°
January, Moderate crowds, average high temperature 21 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
15°
23°
February, High crowds, average high temperature 23 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
24°
March, High crowds, average high temperature 24 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
27°
April, High crowds, average high temperature 27 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
29°
May, High crowds, average high temperature 29 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
30°
June, Moderate crowds, average high temperature 30 degrees Celsius, average low temperature 26 degrees Celsius. Partly sunny.
26°
31°
July, Moderate crowds, average high temperature 31 degrees Celsius, average low temperature 27 degrees Celsius. Partly sunny.
27°
31°
August, Moderate crowds, average high temperature 31 degrees Celsius, average low temperature 27 degrees Celsius. Partly sunny.
27°
30°
September, Low crowds, average high temperature 30 degrees Celsius, average low temperature 26 degrees Celsius. Partly sunny.
26°
29°
October, Low crowds, average high temperature 29 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
25°
November, Low crowds, average high temperature 25 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
Monthly weather averages (˚C)
Check out reviews of Sanctuary hotels guests love
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
10/10 Excellent
"Had modern furniture. Amenities are all there. Breakfast was great! Above average. Staff was nice."
Doubletree by Hilton Fort Myers at Bell Tower Shops
10/10 Excellent
"Great hotel and location and good value. "
Edison Beach House
10/10 Excellent
"Everything was great, clean alot of space n walking distance to time square"
Pink Shell Beach Resort and Marina
10/10 Excellent
"The hotel was spectacular. Just what we were hoping for. Beautiful views from the rooms. Relaxing. A nice adults only section which is ideal for us seniors. Great hot tub, in room tub and breakfast. Good dinner options too without having to leave the property. Staff across the board were spectacular. "
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
10/10 Excellent
"Wonderful breakfast selection. Worth the price for the close proximity to Fort Meyer beach. "
Lani Kai Beachfront Resort
10/10 Excellent
"Clean perfectly located, friendly staff, updated room with an awesome view. Great food on the premises. The only thing we didnt like was the additional charge for parking. "
Allure Suites
10/10 Excellent
"Allure Suites Offers a Home Away From Home! Suites are stocked and very clean!!! Staff is excellent!!!
Love This Place!!
Glenda Fortune "
The Lighthouse Resort Inn & Suites
10/10 Excellent
"All around great place and great location "
Matanzas Inn Bayside Resort and Marina
10/10 Excellent
"got the 2 bdr unit next to office. rooms were great, check inn easy, pool and hot tub made it very enjoyable. my only complaint was i only booked for 1 night. will be my stop when return"
Find out more about Sanctuary