My wife and I loved our stay at Ottantotto in early October. The room (#5) was typical european-sized, but nicely updated. It was spotlessly clean. The bed was very comfortable. Water pressure and the hot water supply were abundant, although we had to run the hot water for quite a while before we received any hot water if nobody in the hotel had used the hot water supply in a while. Each morning's breakfast selection was fresh and tasty.
The hotel staff were exceptionally nice and helpful throughout our stay, and went above and beyond the call of duty to help us with a problem after we left the hotel!
The hotel is conveniently located, and an easy walk across the Arno river into the old town and most of the sites you will visit while there. However, it is far enough away to be peaceful and quiet at night. Many choices are availble for dining in the area.
If you are packing light and plan to do laundry while traveling, there is a 24 hour laundry located directly across the street from the hotel. Be advised that you'll need euros, since the credit card slot was inoperable.
We'll be staying at this hotel again when we return to Florence!