A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Hotels in Defiance

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Where to stay in Defiance?

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

A breakfast bar with a digital menu board, fruit bowls, cereal dispensers, and condiments.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

$93

$110 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

A hotel lobby with a reception desk, seating area, and a large potted plant.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

$82

$97 total

includes taxes & fees

Nov 11 - Nov 12

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

3. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

$128

$150 total

includes taxes & fees

Oct 27 - Oct 28

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

4. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

$114

$134 total

includes taxes & fees

Nov 3 - Nov 4

A hotel room with a bed, bedside tables, a desk, a TV, and a window with curtains.

A laundry room with a front-loading washing machine and stacked dryers.

A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.

5. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

$84

$101 total

includes taxes & fees

Oct 28 - Oct 29

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A spacious living area with a staircase, a large painting, and a chandelier.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A modern bathroom with a large mirror, white vanity, and a bathtub.

6. The Wildwood Hotel

Wildwood

$92

$107 total

includes taxes & fees

Oct 26 - Oct 27

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

7. Residence Inn by Marriott O'Fallon

O'Fallon

$122

$144 total

includes taxes & fees

Nov 20 - Nov 21

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

A spacious lobby with a sofa, a coffee station, and a reception desk.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

$114

$135 total

includes taxes & fees

Nov 19 - Nov 20

An outdoor patio area with wicker furniture and a central fire feature.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

9. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

$101

$118 total

includes taxes & fees

Nov 20 - Nov 21

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

A hotel room with a bathroom, a bed, a nightstand, and a window.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

10. Quality Inn Near Six Flags St. Louis

Pacific

$85

$97 total

includes taxes & fees

Nov 9 - Nov 10

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

A coffee station with two coffee machines and a display of coffee pods and cups.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

$110

$128 total

includes taxes & fees

Oct 25 - Oct 26

Two people in a swimming pool with colorful inflatable rings.

A buffet counter with a variety of food items, including pastries and beverages, and a person serving.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

12. Holiday Inn St. Louis West Six Flags by IHG

Eureka

$130

$151 total

includes taxes & fees

Nov 19 - Nov 20

A spacious lobby with a central round table, two sofas, and a chandelier.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

13. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

$130

$151 total

includes taxes & fees

Oct 26 - Oct 27

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

14. Hyatt Place St. Louis/Chesterfield

Chesterfield

$121

$140 total

includes taxes & fees

Oct 25 - Oct 26

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

15. Comfort Inn Near Six Flags St. Louis

Pacific

$88

$101 total

includes taxes & fees

Nov 11 - Nov 12

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A hotel room with a large bed, two sofas, a desk, and a TV.

An outdoor patio with a beige sofa set, two armchairs, and a table.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

16. Best Western Plus Washington Hotel

Washington

$134

$153 total

includes taxes & fees

Oct 25 - Oct 26

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

17. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

$100

$117 total

includes taxes & fees

Nov 21 - Nov 22

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.

A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

18. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

$64

$74 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor patio with a built-in grill, seating area, and stone walls.

A multi-story hotel with a parking lot in front.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

19. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

$189

$221 total

includes taxes & fees

Oct 28 - Oct 29

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A hotel room with a large bed, a desk with a chair, a television, a mirror, and a wardrobe.

A hotel room with orange furniture, a glass coffee table, a dining area with a table and chairs, and a patterned carpet.

An indoor tennis court with multiple courts, a net, and players.

20. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

$139

$161 total

includes taxes & fees

Oct 30 - Oct 31

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Next weekend

A narrow hallway with a wooden staircase, a sliding door, and a view of a blue car outside.

A kitchen with a built-in microwave, stainless steel sink, wooden shelves, and a window overlooking a backyard.

A small, light blue cabin with a deck, two chairs, and a table.

A compact kitchen with white cabinets, a built-in bench with cushions, and a wooden ladder leading to a loft area.

'the Chardonnay Chalet' Defiance Studio Trail!

Defiance

$132

per night

$395 total

includes taxes & fees

A kitchen with white cabinetry, wooden countertops, a dining table with checkered chairs, and a view of greenery outside.

A hallway with a wooden floor, a chandelier, framed pictures, a mirror, and a door labeled "Farmhouse."

A porch with a red door, two rocking chairs with black and white cushions, and a sign listing activities like reading a book and visiting with friends.

A living room with a red sofa, a checkered sofa, a wooden coffee table, and a cowhide rug. There is a white cabinet and a black pendant light.

'the Ruebling House' Historic Defiance Apartment!

Defiance

$242

per night

$707 total

includes taxes & fees

A spacious kitchen with a large island, wooden cabinets, and a high ceiling with exposed beams.

A spacious living room with a wooden floor, a blue leather armchair, a beige sofa, and a small wooden chest.

A modern kitchen with grey cabinets, stainless steel appliances, and a wooden island.

A bedroom with a bed, pillows, a bedside lamp, and a door leading to another room.

'the Ruebling House': Bright, Modern, & Renovated!

Defiance

$242

per night

$707 total

includes taxes & fees

A modern kitchen with stainless steel appliances, a wooden island, and pendant lighting.

A two-story house with a porch and a garage.

A modern kitchen with a central island, stainless steel appliances, and a large window providing natural light.

A kitchen with a built-in cabinet containing various dishes and a window.

The Ruebling House Cozy Defiance Apartment!

Defiance

$242

per night

$707 total

includes taxes & fees

A spacious living area with a staircase, wooden flooring, a dining table with chairs, a sofa, and a chandelier.

A kitchen with wooden walls, a bar area with stools, a gas stove, and a checkered floor.

A rustic kitchen with a wooden bar, bar stools, and a chandelier.

A rustic dining area with a wooden table, chairs, and a chandelier. A deer head is mounted on the wall above the table.

The Reubling House - Modern-rustic Cabin!

Defiance

$242

per night

$707 total

includes taxes & fees

Go beyond your typical stay in Defiance

Top landmarks in Defiance

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Historic Daniel Boone Home and Heritage Center is just one of the landmarks located 4.3 mi (7 km) from central Defiance, so you might want to stop by for a few pics during your trip.

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Sugar Creek Winery

8.0/10 (1 review)

Check out reviews of Defiance hotels guests love

Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

10/10 Exceptional

Courtyard by Marriott St. Louis Chesterfield

Chesterfield

10/10 Exceptional

I will definitely stay here again when work brings me back to the area. I arrived late at night and Angela was working the front desk. I had mistakenly made my reservation for the wrong date and she helped me through the process to change the date. AND, she did not charge me a fee even though it was a non-refundable reservation. She was so great to work with and understanding of my silly mistake.

Sarah

Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

10/10 Exceptional

JOVITA

Hyatt Place St. Louis/Chesterfield

Chesterfield

10/10 Exceptional

Anonymous traveler

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A hotel room with two beds, a desk, a blue sofa, and a TV.

A Holiday Inn Express hotel with a modern design, featuring a covered entrance and multiple windows.

A modern hotel lobby with a high ceiling, a central seating area with sofas and a coffee table, and a flat-screen TV mounted on the wall.

A modern hotel breakfast area with a central island, buffet setup, and a large window providing a view.

A hotel room with a bed, a desk with a computer, a television, a sofa, and a window with a view.

A spacious lobby with a high ceiling, a flat-screen TV mounted on the wall, and a seating area with sofas and ottomans.

Drury Inn & Suites Southwest St. Louis

Valley Park

10/10 Exceptional

Tonya

A brick building with a metal railing and a staircase leading to a second-floor balcony.

A door with a keypad lock, a brick wall, and a window with blinds.

A modern hotel room with a bed, a desk, a chair, a TV, and a bathroom with a sink and mirror.

A balcony with a view of a brick building, a parking lot, and a clear sky.

River Sirens Hotel

Washington

10/10 Exceptional

Greg

Frequently Asked Questions

What hotels do travelers recommend in Defiance?

Guests like The Wildwood Hotel and Sleep Inn & Suites O'Fallon MO - Technology Drive.

Can I book refundable accommodations in Defiance?

If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Defiance be like during my vacation?

July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.

Why should I book my Defiance hotel through Hotels.com?

There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.