Hotels in Byron

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Check prices for these dates

This weekend
Jul 31 - Aug 2
Next weekend
Aug 7 - Aug 9

Where to stay in Byron?

Interior entrance

Baymont by Wyndham Kasson Rochester Area

Baymont by Wyndham Kasson Rochester Area
2.5 star property
Kasson
6.6 out of 10, (398 reviews)
Discover peaceful comfort at this family-friendly retreat with an indoor pool for morning swims and a hot tub for evening relaxation. Free breakfast, WiFi, and parking enhance your stay near Zumbro Valley Golf Course and Sunset Trail Park.
The price is $60
$65 total
includes taxes & fees
Aug 26 - Aug 27
Baymont by Wyndham Kasson Rochester Area
Lobby

Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (677 reviews)
Just minutes from world-renowned Mayo Clinic, this hotel offers an indoor pool for year-round relaxation. Guests love the helpful staff and spotless rooms. Enjoy free breakfast, WiFi, parking, and easy access to Badger Ridge Park.
The price is $85
$98 total
includes taxes & fees
Aug 23 - Aug 24
Sleep Inn & Suites West-Near Medical Center
Exterior

Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
8.8 out of 10, Excellent, (630 reviews)
Conveniently located just 10 minutes from Mayo Clinic, this Rochester hotel offers comfort with an indoor pool and relaxing hot tub. Free parking and a fitness center enhance your stay while medical facilities remain easily accessible.
The price is $103
$119 total
includes taxes & fees
Aug 23 - Aug 24
Comfort Inn & Suites West - Medical Center
Restaurant

Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1,003 reviews)
Just a short drive from Mayo Clinic, this welcoming hotel offers a refreshing indoor pool and soothing hot tub. Guests love the complimentary breakfast, free WiFi, and convenient parking. The helpful staff and 24-hour fitness center ensure a comfortable stay near Northern Hills Golf Course.
The price is $103
$118 total
includes taxes & fees
Aug 9 - Aug 10
Hampton Inn & Suites Rochester-North
Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, bed sheets

Quality Inn near Medical Center

Quality Inn near Medical Center
2.5 star property
Rochester
7.8 out of 10, Good, (931 reviews)
Just 10 minutes from Mayo Clinic, this Rochester hotel offers comfort with an indoor pool, fitness center, and complimentary breakfast. Business travelers appreciate the free parking and helpful staff, while nearby attractions provide leisure options.
The price is $67
$77 total
includes taxes & fees
Aug 17 - Aug 18
Quality Inn near Medical Center
Exterior

Staybridge Suites Rochester - Commerce Dr NW by IHG

Staybridge Suites Rochester - Commerce Dr NW by IHG
3.0 star property
Rochester
8.8 out of 10, Excellent, (550 reviews)
Feel at home in this Rochester hotel where complimentary breakfast fuels your day. The indoor pool offers year-round relaxation after visiting Mayo Clinic, just a 10-minute drive away. Clean rooms and helpful staff create a comfortable stay near Badger Ridge Park.
The price is $124
$143 total
includes taxes & fees
Aug 2 - Aug 3
Staybridge Suites Rochester - Commerce Dr NW by IHG
In-room safe, desk, iron/ironing board, cribs (free)

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
2.0 star property
Rochester
8.0 out of 10, Very Good, (1,005 reviews)
Peaceful accommodations just a 10-minute drive from Mayo Clinic with free WiFi, parking, and daily on-the-go breakfast. The fitness center offers workout options while nearby restaurants and attractions provide convenient exploration opportunities.
The price is $70
$80 total
includes taxes & fees
Aug 26 - Aug 27
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Studio, 2 Double Beds, Non Smoking | Desk, iron/ironing board, WiFi (free), bed sheets

Extended Stay America Suites Rochester North

Extended Stay America Suites Rochester North
2.5 star property
Rochester
7.6 out of 10, Good, (718 reviews)
This extended-stay hotel sits just 10 minutes from Mayo Clinic, offering convenient access to medical facilities. Enjoy complimentary WiFi, daily on-the-go breakfast, and free parking, plus nearby snowmobiling for winter fun.
The price is $68
$79 total
includes taxes & fees
Jul 29 - Jul 30
Extended Stay America Suites Rochester North
Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (1,005 reviews)
Minutes from Mayo Clinic and St. Mary's Campus, this hotel offers free breakfast, parking, and WiFi. Enjoy a swim in the indoor pool, unwind in the hot tub, or grab American cuisine at Wildwood Sports Bar. Nearby restaurants, shops, and attractions await.
The price is $94
$108 total
includes taxes & fees
Aug 2 - Aug 3
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2 indoor pools

TownePlace Suites by Marriott Rochester

TownePlace Suites by Marriott Rochester
3.0 star property
Rochester
8.8 out of 10, Excellent, (597 reviews)
The price is $98
$113 total
includes taxes & fees
Aug 3 - Aug 4
TownePlace Suites by Marriott Rochester
Terrace/patio

Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
Rochester
9.6 out of 10, Exceptional, (1,003 reviews)
Relax at this Rochester hotel just 5 minutes from Mayo Clinic. Splash in 2 indoor pools or work out at the fitness center. The comfortable rooms include sofa beds and refrigerators, while free breakfast, WiFi, and parking add value to your stay.
The price is $118
$136 total
includes taxes & fees
Aug 13 - Aug 14
Home2 Suites by Hilton Rochester Mayo Clinic Area
Courtyard

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (1,013 reviews)
This health-minded hotel offers a refreshing indoor pool, hot tub, and 24-hour fitness center. Just a 15-minute walk to Mayo Clinic Campus, EVEN Kitchen & Bar serves breakfast and dinner. Clean rooms and helpful staff ensure a comfortable stay near Kutzky Park.
The price is $91
$106 total
includes taxes & fees
Aug 7 - Aug 8
EVEN Hotel Rochester - Mayo Clinic Area by IHG
2 indoor pools

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
2.5 star property
Kutzky Park
8.0 out of 10, Very Good, (1,031 reviews)
Relax in this quiet Rochester retreat featuring 2 indoor pools and a hot tub. Just minutes from Mayo Clinic with free breakfast, WiFi, and parking. Nearby Kutzky Park and Cascade Lake Beach offer outdoor escapes after a busy day.
The price is $84
$97 total
includes taxes & fees
Jul 28 - Jul 29
Med City Inn & Suites - Mayo Clinic Area
Reception

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,007 reviews)
Unwind in this tranquil retreat just 5 minutes from Mayo Clinic. After enjoying the free breakfast, take a refreshing dip in the indoor pool or relax in the hot tub. The helpful staff, free WiFi, and convenient parking enhance your stay near Apache Mall.
The price is $83
$96 total
includes taxes & fees
Aug 20 - Aug 21
Hampton Inn Rochester-South
Exterior

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park
9.2 out of 10, Wonderful, (799 reviews)
The price is $113
$130 total
includes taxes & fees
Jul 31 - Aug 1
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Free daily full breakfast

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,006 reviews)
Wake up to a free full breakfast at this quiet hotel just 5 minutes from Mayo Clinic. Enjoy complimentary WiFi and parking, plus a 24-hour fitness center. The helpful staff and convenient location near Olmsted County Fairgrounds make this a peaceful choice.
The price is $71
$82 total
includes taxes & fees
Aug 23 - Aug 24
Econo Lodge Mayo Clinic Area
Front of property

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.4 out of 10, Good, (1,081 reviews)
Situated just a 10-minute drive from Mayo Clinic, this hotel offers a complimentary buffet breakfast each morning. Guests appreciate the spotless rooms, free WiFi, and parking. The fitness center and proximity to local attractions add extra value.
The price is $76
$87 total
includes taxes & fees
Aug 2 - Aug 3
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Exterior

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park
8.6 out of 10, Excellent, (818 reviews)
Just a 5-minute drive from Mayo Clinic, this Rochester hotel offers a refreshing indoor pool and fitness center. Wake up to free breakfast before exploring nearby Kutzky Park or Cascade Lake Beach. Guests love the helpful staff and convenient free parking.
The price is $118
$136 total
includes taxes & fees
Aug 27 - Aug 28
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Reception

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (538 reviews)
Within 10 minutes of Mayo Clinic, this welcoming Rochester hotel offers free breakfast, WiFi, and parking. Swim in the indoor pool, stay fit at the on-site gym, and experience friendly service that guests consistently praise.
The price is $81
$93 total
includes taxes & fees
Aug 2 - Aug 3
Spark by Hilton Rochester South
WiFi (free), bed sheets

Motel 6 Rochester, MN

Motel 6 Rochester, MN
2.0 star property
Rochester
5.8 out of 10, (450 reviews)
This Rochester motel provides free WiFi and parking, plus 24-hour front desk service for late arrivals. Located near Mayo Clinic Hospital and Assisi Heights, it's a practical base for medical appointments or exploring nearby Kutzky Park Tennis Center.
The price is $55
$63 total
includes taxes & fees
Jul 30 - Jul 31
Motel 6 Rochester, MN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Byron

Oxbow Park

8.8/10 (5 reviews)
Oxbow Park is 3.4 mi (5.5 km) from central Byron, why not stop by during your stay. Our travelers also like this walkable area for its restaurants. If you like Oxbow Park, you'll love Douglas State Trail Head Rochester, just a short drive away.
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Check out reviews of Byron hotels guests love

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent
"The hotel is dated, but the staff was great and understanding and the rooms were clean. We had a couple of minor inconveniences but the staff was quick to resolve them."
Kathy 2-night trip
Posted less than an hour ago
Med City Inn & Suites - Mayo Clinic Area

Frequently asked questions

What hotels do travelers recommend in Byron?
Guests like Kahler Grand Hotel, Med City Inn & Suites - Mayo Clinic Area and Kahler Inn and Suites - Mayo Clinic Area.
Can I book refundable accommodations in Byron?
If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Byron be like during my vacation?
July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.
Why should I book my Byron hotel with Hotels.com?
There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.