Hotels in Santa Isabel

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Apr 12 - Apr 13
Tomorrow
Apr 13 - Apr 14
Next weekend
Apr 17 - Apr 19
In two weeks
Apr 24 - Apr 26

Where to stay in Santa Isabel?

Exterior
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Cocoloco - Catamaran Lagoon 52F SAN BLAS
3.0 star property
Narganá
  • cleanliness
    Sail the stunning San Blas archipelago on a floating paradise with sea views.
The price is $2,045
$2,250 total
includes taxes & fees
Apr 13 - Apr 14
Cocoloco - Catamaran Lagoon 52F SAN BLAS
View from property
Cabañas Isla Nubesidub San Blas
Cabañas Isla Nubesidub San Blas
2.0 star property
Narganá
The price is $384
$422 total
includes taxes & fees
Apr 27 - Apr 28
Cabañas Isla Nubesidub San Blas
Exterior
Cabañas Nalunega San Blas
Cabañas Nalunega San Blas
2.0 star property
Narganá
The price is $355
$391 total
includes taxes & fees
Apr 29 - Apr 30
Cabañas Nalunega San Blas
Property grounds
Cabins on paradise San Blas island
Cabins on paradise San Blas island
2.0 star property
Narganá
  • cleanliness
    Explore Panama's San Blas island from a rustic cabin steps away from paradise.
The price is $269
$296 total
includes taxes & fees
Apr 14 - Apr 15
Cabins on paradise San Blas island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Learn more about Santa Isabel

While in the area, you can enjoy nearby attractions like Porvenir Museum.

See all hotels in Santa Isabel
Scenic Coiba Island Aerial View

Check out reviews of Santa Isabel hotels guests love

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

10/10 Excellent
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door. "
Ryan 4-night trip
Posted 1 month ago
Private Ocean-Front Cabin with private bathroom on San Blas Island

Frequently asked questions

Can I book a refundable accommodation in Santa Isabel?
If you need the flexibility to change your plans to Santa Isabel, most hotels provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Isabel be like during my vacation?
With an average temperature of 78°F during the coldest months, Santa Isabel is a great place to visit any time of year.
Why should I book my Santa Isabel accommodation with Hotels.com?
There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.