Hotels in Santa Clara

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Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B
3.0 star property
Rio Hato
9.8 out of 10, Exceptional, (69 reviews)
Tropical relaxation awaits at this golf B&B featuring an outdoor pool, massage services, and a welcoming bar. Just minutes from Playa Blanca and Farallón Beach, with airport shuttle service available 24 hours for seamless travel.
The price is $120
$120 total
includes taxes & fees
Jun 21 - Jun 22
Villa Botero By Casa Mojito B&B

las cabañas

las cabañas
3.0 star property
La Ermita
The price is $56
$62 total
includes taxes & fees
Jun 21 - Jun 22
las cabañas

Hotel Eclipse

Hotel Eclipse
3.0 star property
San Jose
8.8 out of 10, Excellent, (82 reviews)
Bask in the sun at 2 outdoor pools or melt tension with deep-tissue massages. Blue Wolf Restaurant serves fusion meals while you're minutes from Los Cajones de Chame and Cerro Picacho. Free breakfast, WiFi, and parking enhance the value.
The price is $71
$78 total
includes taxes & fees
Jun 21 - Jun 22
Hotel Eclipse

Nomada Republic Hotel El Valle

Nomada Republic Hotel El Valle
3.0 star property
El Valle de Anton
9.4 out of 10, Exceptional, (69 reviews)
Wake up to mountain views at this El Valle de Anton retreat, just minutes from Chorro Macho Waterfall. Enjoy complimentary breakfast before exploring nearby attractions, then unwind at the hotel bar or savor local cuisine at the onsite restaurant.
The price is $88
$97 total
includes taxes & fees
Jun 22 - Jun 23
Nomada Republic Hotel El Valle

Hotel La Compania Del Valle

Hotel La Compania Del Valle
5.0 star property
El Valle de Anton
9.8 out of 10, Exceptional, (121 reviews)
Immerse yourself in El Valle de Anton's natural beauty while enjoying spa treatments, a seasonal outdoor pool, and rooftop terrace views. Just minutes from cultural attractions with convenient amenities like free WiFi and parking.
The price is $234
$257 total
includes taxes & fees
Jun 23 - Jun 24
Hotel La Compania Del Valle

Hotel Las Catalinas Antón

Hotel Las Catalinas Antón
2.5 star property
Anton
8.6 out of 10, Excellent, (36 reviews)
Escape to colonial-style accommodation in Anton, where a lazy river winds through the grounds. Two coffee shops and Cafe Qbano Restaurante serve meals throughout the day, while free WiFi and parking add convenience. Anton Park is just minutes away.
The price is $38
$42 total
includes taxes & fees
Jun 21 - Jun 22
Hotel Las Catalinas Antón

Gran Evenia Bijao - All Inclusive

Gran Evenia Bijao - All Inclusive
3.5 star property
Rio Hato
8.2 out of 10, Very Good, (1,000 reviews)
Unwind at this Rio Hato beach haven with 3 pools and 4 restaurants serving local fare. Near Playa Blanca and Farallón Beach, this all-inclusive escape offers a nightclub, 3 bars, and a free kids' club.
The price is $149
$164 total
includes taxes & fees
Jun 25 - Jun 26
Gran Evenia Bijao - All Inclusive

Casa Madre Tierra

Casa Madre Tierra
3.0 star property
Los Llanitos
9.8 out of 10, Exceptional, (47 reviews)
Surrounded by nature near Valley of Square Trees, this serene mountain retreat offers complimentary breakfast and parking. Relax in the outdoor pool, enjoy a massage, or savor local flavors at the restaurant and bar. The tranquil terrace provides the perfect spot for unwinding.
The price is $194
$213 total
includes taxes & fees
Jun 21 - Jun 22
Casa Madre Tierra

Hostal Las Catalinas Ecológicas

Hostal Las Catalinas Ecológicas
2.5 star property
El Valle de Anton
7.0 out of 10, Good, (4 reviews)
Immerse in nature at this ecological hostel with on-site hiking and mountain biking paths. Just minutes from Chorro El Macho and Chorro de las Mozas waterfalls, this green haven offers conference facilities and helpful concierge services for adventure seekers.
The price is $41
$45 total
includes taxes & fees
Jun 21 - Jun 22
Hostal Las Catalinas Ecológicas

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
5.0 star property
El Chiru
9.2 out of 10, Wonderful, (752 reviews)
Escape to this luxury resort near Playa Blanca with a golf course and 7 restaurants serving international cuisine. Enjoy deep-tissue massages at the spa, swim in multiple pools, or relax with beachside drinks on sun loungers.
The price is $220
$242 total
includes taxes & fees
Jul 2 - Jul 3
The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Golden Frog Inn

The Golden Frog Inn
3.0 star property
El Valle de Anton
9.6 out of 10, Exceptional, (282 reviews)
The price is $107
$117 total
includes taxes & fees
Jun 23 - Jun 24
The Golden Frog Inn

San Carlos Surf Resort & Eco Lodge

San Carlos Surf Resort & Eco Lodge
3.0 star property
Costa Esmeralda
6.4 out of 10, (5 reviews)
The price is $78
$102 total
includes taxes & fees
Jun 26 - Jun 27
San Carlos Surf Resort & Eco Lodge

La Casita de Don Daniel

La Casita de Don Daniel
2.0 star property
El Valle de Anton
9.4 out of 10, Exceptional, (56 reviews)
The price is $36
$40 total
includes taxes & fees
Jun 26 - Jun 27
La Casita de Don Daniel

Town Center Paradise in Playa Blanca

Town Center Paradise in Playa Blanca
2.5 star property
Rio Hato
7.8 out of 10, Good, (56 reviews)
Tropical retreat in Rio Hato featuring an outdoor pool and convenient snack bar. Each room includes refrigerators and microwaves for easy vacation dining. Just a 10-minute walk to Playa Blanca, with Farallón Beach nearby for sun-soaked adventures.
The price is $98
$108 total
includes taxes & fees
Jun 21 - Jun 22
Town Center Paradise in Playa Blanca

Casa Caracol Boutique Hotel

Casa Caracol Boutique Hotel
2.0 star property
Las Uvas
9.0 out of 10, Wonderful, (32 reviews)
The price is $89
$98 total
includes taxes & fees
Jun 22 - Jun 23
Casa Caracol Boutique Hotel

Hotel Campestre

Hotel Campestre
3.0 star property
El Valle de Anton
8.4 out of 10, Very Good, (266 reviews)
Wake up to stunning mountain vistas at this tranquil hotel in El Valle de Anton. Just minutes from Square Trees Nature Trail and Anton Valley Museum, you'll find lush gardens and a welcoming restaurant. Unwind with a drink at the bar while soaking in the natural beauty all around.
The price is $101
$111 total
includes taxes & fees
Jun 21 - Jun 22
Hotel Campestre

Hotel Coronado Inn

Hotel Coronado Inn
3.0 star property
Las Lajas
8.2 out of 10, Very Good, (84 reviews)
The price is $69
$76 total
includes taxes & fees
Jun 21 - Jun 22
Hotel Coronado Inn

San Carlos Beach Inn

San Carlos Beach Inn
3.0 star property
San Carlos
8.4 out of 10, Very Good, (38 reviews)
Absorb breathtaking panoramas from the rooftop terrace at this beachside haven. Located near Playa El Palmar and Playa La Ensenada, the hotel features Panama Cafe serving 3 daily meals and free WiFi for seamless connectivity during your coastal escape.
The price is $32
$35 total
includes taxes & fees
Jun 21 - Jun 22
San Carlos Beach Inn

Grand Decameron Panama, A Trademark All Inclusive Resort

Grand Decameron Panama, A Trademark All Inclusive Resort
3.5 star property
Rio Hato
7.4 out of 10, Good, (1,000 reviews)
Escape to this all-inclusive resort with free cabanas on the beach. Enjoy seafood at El Canal, unwind with massages, or play volleyball and tennis. With 8 bars and a marina, you're just minutes from Farallón Beach and Playa Blanca.
The price is $161
$177 total
includes taxes & fees
Jun 30 - Jul 1
Grand Decameron Panama, A Trademark All Inclusive Resort

Mi Casa Asi de Grande

Mi Casa Asi de Grande
3.0 star property
El Coco
8.0 out of 10, Very Good, (30 reviews)
Immerse yourself in tranquility at this spa retreat offering deep-tissue massages, body wraps, and scrubs. Located near Penonomena History Museum and 8 de Diciembre Park, the hotel includes free WiFi, parking, and an onsite café.
The price is $28
$52 total
includes taxes & fees
Jun 21 - Jun 22
Mi Casa Asi de Grande
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Clara

The region around Santa Clara is home to attractions such as Playa Blanca and Santa Clara Beach.

Santa Clara, Panama

Check out reviews of Santa Clara hotels guests love

Frequently asked questions

What accommodations do travelers recommend in Santa Clara?
Can I book a refundable hotel in Santa Clara?
If you're looking for the flexibility to change your plans to Santa Clara, most accommodations provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Santa Clara if I want a vacation home instead of a traditional hotel?
If you're looking for a good alternative to a hotel, look over our selection of 6 vacation homes.
What will the weather in Santa Clara be like during my visit?
With an average temperature of 78°F, Santa Clara is a great place if you want to enjoy the sunshine year all year long.
Why should I book my Santa Clara hotel through Hotels.com?
There are plenty of reasons to book your Santa Clara travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.