Hotels in Cairo

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Check prices for these dates

Tonight
Sep 21 - Sep 22
Tomorrow
Sep 22 - Sep 23
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Where to stay in Cairo?

A hotel lobby with a reception desk, seating area, and a large window.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
$71
$79 total
includes taxes & fees
Oct 2 - Oct 3
Quality Inn Cairo I-57
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
$60
$66 total
includes taxes & fees
Sep 23 - Sep 24
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.
A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
$66
$74 total
includes taxes & fees
Sep 24 - Sep 25
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.
A bathroom with a sink, mirror, towel rack, shower, and toilet.

4. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
$77
$85 total
includes taxes & fees
Sep 23 - Sep 24
Eagle Inn Charleston
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
A reception desk with a computer, a framed picture on the wall, and a vase with flowers.
A bathroom with yellow walls, a wooden cabinet, a sink, a mirror, and a hanging towel rack.
A motel with a red roof and beige walls, a parking lot, and a signboard.

5. La Center Motel

La Center Motel
La Center
$54
$63 total
includes taxes & fees
Sep 23 - Sep 24
La Center Motel
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.
A bedroom with a wooden bed, a bedside table with a lamp, a window with curtains, and a view of the outdoors.
A small, single-story house with a front porch and a gravel driveway.
A kitchen with white cabinets, a stainless steel refrigerator, a coffee maker, and a trash can.

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
$149
$290 total
includes taxes & fees
Sep 28 - Sep 29
Quiet Country Stay: Modern Home Near Paducah
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Our prices for hotels in Cairo are cheapest in September
Price trends for hotels in Cairo
Pricing is based on two traveler single night rates
View properties in September
Typical weather for Cairo
September
High 28°C / low 17°C. Sunny most days.
View properties in September
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Monthly weather averages (˚C)

Top landmarks in Cairo

Fort Defiance State Park

7.4/10 (15 reviews)
Fort Defiance State Park is 2.3 mi (3.7 km) from central Cairo, why not stop by during your stay.
See properties

Learn more about Cairo

Cairo is well-known for its attractions such as Mississippi River and Ohio River Valley. The city has something for everyone including sights like Fort Defiance State Park within a small-town setting.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Check out reviews of Cairo hotels guests love

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Súper affordable pricing, and the property was clean and comfortable! Complimentary breakfast was a plus!"
Brianna 1-night trip
Posted 5 hours ago
Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

8/10 Good
"Overall it was excellant, other then the toilet running constantly... Pool could have been cleaner, considering the heat-wave they were having............."
Mark E 13-night trip
Posted 8 days ago
The Riverstone Hotel Charleston-Sikeston
Quality Inn Cairo I-57

Quality Inn Cairo I-57

8/10 Good
"Good service,nice stuff and no complaints"
Santiago 1-night trip
Posted 11 days ago
Quality Inn Cairo I-57
La Center Motel

La Center Motel

10/10 Excellent
"Great AC unit in the room!"
Jonathan 1-night trip
Posted 2 months ago
La Center Motel
Eagle Inn Charleston

Eagle Inn Charleston

10/10 Excellent
"Great"
Jackson 1-night trip
Posted 6 months ago
Eagle Inn Charleston

Frequently asked questions

What accommodations do travelers like in Cairo?
Guests like Quality Inn Cairo I-57 and Eagle Inn Charleston.
Can I book refundable accommodations in Cairo?
If you're looking for the flexibility to change your travel plans to Cairo, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where should I stay in Cairo if I'm looking for an affordable accommodation?
Quality Inn Cairo I-57 is an accommodation you might want to consider that'll save you money.
What will the weather in Cairo be like during my trip?
The warmest months in Cairo are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 41°F. The rainiest months are April and March.
Why should I book my Cairo accommodation with Hotels.com?
There are plenty of reasons to book your Cairo travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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