An aerial view of a town with industrial buildings, roads, and green areas.

Hotels in St. Charles

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Where to stay in St. Charles?

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A cozy living room with a fireplace, a staircase, and a dining area.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

1. Stone Mill Hotel & Suites

Lanesboro

$105

$113 total

includes taxes & fees

Sep 14 - Sep 15

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

A breakfast area with a coffee station, a refrigerator, and a dining table with chairs.

A modern room with two sofas, a coffee table, and large windows with curtains.

A reception area with a counter, a clock, a desk with a computer, and a framed picture on the wall.

2. Days Inn by Wyndham Winona

Winona

$68

$76 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A multi-story hotel with a prominent "American" sign, a parking lot with several cars, and a landscaped entrance area.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

3. AmericInn by Wyndham Winona

Winona

$118

$132 total

includes taxes & fees

Oct 11 - Oct 12

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A bar with wooden stools and a neon sign.

4. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

$77

$89 total

includes taxes & fees

Sep 18 - Sep 19

A two-story house with a porch and a covered entryway.

A hallway with a wooden floor, a chandelier, a bust sculpture, and a door leading to another room.

A bedroom with a wooden wardrobe, a bedside table with a lamp, and a bed with white bedding and a red pillow.

A porch with a white door labeled "WENNESON" and a welcome wreath.

5. The Wen Inn formerly Andor Wenneson

Peterson

$113

$123 total

includes taxes & fees

Sep 14 - Sep 15

A modern hotel lobby with a reception desk, seating area, and a dining space.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A hotel room with a bed, desk, chair, and a bathroom.

A Holiday Inn Express building with a stone facade and illuminated signage.

6. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

$96

$111 total

includes taxes & fees

Sep 20 - Sep 21

A hotel pool area with multiple lounge chairs, a pool, and a second-floor balcony with windows.

A spacious lobby with a stone fireplace, leather seating, a staircase with glass railings, and a view of the outside through large windows.

A bar area with wooden bar stools, a counter, and a menu board.

A brick building with a sign reading "Riverport Inn & Suites" and two flags.

7. Express Suites Riverport Inn & Suites

Winona

$120

$134 total

includes taxes & fees

Sep 14 - Sep 15

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

8. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

$76

$87 total

includes taxes & fees

Sep 20 - Sep 21

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

A hotel with a covered entrance, multiple floors, and a parking lot.

9. Spark by Hilton Rochester South

Rochester

$89

$103 total

includes taxes & fees

Sep 20 - Sep 21

A multi-story building with a balcony, surrounded by various potted plants and flowers.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

A bedroom with a four-poster bed, a sofa, a desk, and a fireplace.

A porch with a variety of potted plants and flowers, a sign reading "OFFICE Welcome to Green Gables," and a door with a green doorbell.

10. Green Gables Inn

Lanesboro

$108

$116 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A modern kitchen with granite countertops, a built-in microwave, and a sink. There are two wooden chairs and a small table.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

11. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

$94

$108 total

includes taxes & fees

Sep 18 - Sep 19

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

12. Hampton Inn Rochester-South

Rochester

$106

$122 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A reception desk with a wooden finish, a large illuminated 'C' sign, and a modern light fixture on the ceiling.

A gym with treadmills, elliptical machines, and a stationary bike.

A conference room with round tables and chairs, white walls, and a carpeted floor.

13. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

$84

$97 total

includes taxes & fees

Oct 13 - Oct 14

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A compact laundry area with a washing machine, dryer, and a water fountain.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

14. Econo Lodge Mayo Clinic Area

Rochester

$70

$81 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a desk with a chair, a TV, and a large waterfall painting on the wall.

A breakfast area with a wooden wall, a clock, and a coffee machine.

An outdoor patio with a table and chairs, a red umbrella, and a view of trees and a sunset.

A reception area with a modern design, featuring a check-in counter, a door, and a small seating area with red stools.

15. Super 8 by Wyndham Winona MN

Winona

$61

$69 total

includes taxes & fees

Sep 20 - Sep 21

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel room with two beds, a desk, a chair, a television, and a kitchenette.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

16. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

$101

$116 total

includes taxes & fees

Sep 18 - Sep 19

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

A modern restaurant with a counter, seating area, and a TV screen.

A modern lounge area with a sofa, chairs, and tables.

17. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

$122

$141 total

includes taxes & fees

Sep 25 - Sep 26

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

18. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

$112

$128 total

includes taxes & fees

Sep 19 - Sep 20

A hotel room with two beds, a desk, a chair, and a lamp.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

19. Country Trails Inn & Suites

Preston

$126

$140 total

includes taxes & fees

Sep 14 - Sep 15

An indoor swimming pool with clear water, wooden flooring, and a ceiling with wooden beams and lights.

A hotel room with two beds, a desk, a chair, a television, and a window with curtains.

A gym with treadmills, an elliptical, and a water station.

A room with a TV mounted on the wall, a wooden table, and two patterned armchairs.

20. Med City Inn & Suites - Mayo Clinic Area

Kutzky Park

$71

$82 total

includes taxes & fees

Sep 14 - Sep 15

View all properties

Go beyond your typical stay in St. Charles

Learn more about St. Charles

St. Charles is well-known for its attractions such as Whitewater State Park and Whitewater River.

See all hotels in St. Charles

Check out reviews of St. Charles hotels guests love

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern interior with a large dining table, sofas, and a kitchen area.

The Berkman

Folwell

10/10 Exceptional

denise

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A conference room with a long table, multiple chairs, and decorative wall art.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park

10/10 Exceptional

Anonymous traveler

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A hotel room with a large round table, two sofas, a TV, and a bed.

A person at a checkout counter in a store, with various snack items and a sign indicating a price of $1.50.

A sign instructing to clean up after dogs and dispose of waste, with a Poopy Pouch attached.

Candlewood Suites Rochester Mayo Clinic Area by IHG

Rochester

10/10 Exceptional

Ashley

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

Aspen Suites

Rochester

10/10 Exceptional

Julie

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester

10/10 Exceptional

Anonymous traveler

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

A modern kitchen with wooden cabinets, a granite countertop, and a stainless steel stove.

Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester

10/10 Exceptional

miriam sue

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

A reception area with a wooden reception desk, a clock, and a wall-mounted display.

A restaurant with a bar area, wooden chairs, and a stone wall.

A hotel room with a sofa, two beds, a large window, and a framed artwork on the wall.

Kahler Inn and Suites - Mayo Clinic Area

Downtown Rochester

10/10 Exceptional

James

A hotel lobby with two leather armchairs, a small round table, a 'WELCOME' sign, and a 'TRASH CAN' sign on the wall.

A hotel reception area with a black reception desk, a 'WELCOME' sign, a bench, and two armchairs.

A multi-story hotel with a brick facade, a covered lobby entrance, and a parking lot with several cars.

Extended Stay America Suites Rochester North

Rochester

10/10 Exceptional

Daniel

Stone Mill Hotel & Suites

Lanesboro

10/10 Exceptional

Scott

Green Gables Inn

Lanesboro

10/10 Exceptional

RICHARD

A table set for a meal with various dishes, glasses of orange juice, and a vase with flowers.

A grand staircase with a floral carpet, wooden balustrades, and a chandelier.

A room with a portrait framed in gold, red curtains, and a table with ornate candle holders.

A spacious room with wooden paneling, a chandelier, a fireplace, and a large rug.

Alexander Mansion Bed and Breakfast

Historic Downtown Winona

10/10 Exceptional

We stayed in the Alexander Suite, which was ideal for us. King size bed, Victorian charm, tidy bathroom with tub, shower and amenities. Enjoyed the Watkins lotion. The room has an adjacent sitting room perfect for coffee, tea, or relaxing. Don't forget to write something in the journal. The host, Richard, is super nice and so knowledgeable about the area. The huge breakfast consists of 5 courses. Fruit parfait, fresh baked bread that is to die for. The blueberry was our favorite. The main...

Laila and David

Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

10/10 Exceptional

Craig

Hampton Inn Rochester-South

Rochester

10/10 Exceptional

Steven

Days Inn by Wyndham Winona

Winona

10/10 Exceptional

Jeanine

Frequently Asked Questions

What accommodations do travelers recommend in St. Charles?

White Valley Motel is an accommodation that is popular with guests.

Can I book refundable accommodations in St. Charles?

If you need the flexibility to change your plans to St. Charles, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in St. Charles be like during my vacation?

July and August are typically the warmest months in St. Charles when the average temp is 67°F. January and February are the coldest months when the average temperature is 22°F. June and May are the months with the most rain.

Why should I book my St. Charles accommodation with Hotels.com?

There are plenty of reasons to book your St. Charles travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.