Hotels in Santee

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Oct 16 - Oct 18

Where to stay in Santee?

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

1. Tru By Hilton Santee

Santee

$101

$112 total

includes taxes & fees

Oct 14 - Oct 15

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

2. Hampton Inn Santee-I-95

Santee

$110

$122 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

3. Baymont by Wyndham Santee

Santee

$80

$89 total

includes taxes & fees

Oct 8 - Oct 9

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

4. Fairfield Inn & Suites by Marriott Santee

Santee

$139

$154 total

includes taxes & fees

Oct 14 - Oct 15

A swimming pool with a tiled deck, chairs, and a view of the outdoors through large windows.

A modern lounge area with seating, tables, and a fireplace.

A breakfast box with a green label on a kitchen counter.

A modern bathroom with a sink, toilet, and shower.

5. Holiday Inn Santee by IHG

Santee

$104

$115 total

includes taxes & fees

Oct 18 - Oct 19

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

6. Best Western Plus Santee Inn

Santee

$131

$145 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

7. Comfort Inn & Suites Santee

Santee

$103

$114 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

A motel with a brick facade, a covered entrance, and a satellite dish.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

8. Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Oct 11 - Oct 12

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

9. Quality Inn & Suites Santee I-95

Santee

$54

$65 total

includes taxes & fees

Oct 28 - Oct 29

A two-story building with a beige facade, large windows, and a central entrance.

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A modern bathroom with a sink, toilet, and shower area.

10. Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Oct 14 - Oct 15

A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.

A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'

A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.

A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

11. Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

A building with a red roof, a yellow door, and a brick facade.

12. Econo Lodge Santee

Santee

$68

$75 total

includes taxes & fees

Nov 1 - Nov 2

Lobby

A gym with treadmills, an elliptical, dumbbells, and a bench.

A hotel room with two beds, a desk, and a chair.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

13. Ramada by Wyndham Santee I-95

Santee

$88

$98 total

includes taxes & fees

Oct 13 - Oct 14

A fire extinguisher, a water dispenser, a staircase, and a laundry area.

A room with a window overlooking a parking area, a shelf with various snacks, and a chair with a towel.

A hotel lobby with a reception desk, a staircase, and signs for restrooms and the office.

A building entrance with a covered walkway, large windows, and a parking area with directional arrows.

14. Ashburn Inn Manning I 95

Manning

$62

$69 total

includes taxes & fees

Oct 8 - Oct 9

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A tent with two beds, a small table, and a chair.

A modern, two-story mobile home with a metal exterior, large windows, and a visible kitchen area.

A modern room with a grey sofa, a small table, and a view of a lake and parked car through large glass doors.

15. Bells Marina & Resort

Eutawville

$82

$94 total

includes taxes & fees

Nov 2 - Nov 3

A two-story building with a sign reading "PachTree Inn".

A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.

A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.

A compact hotel room with a kitchenette, a television, a desk, and a chair.

16. Peach Tree Inn

St. George

$58

$63 total

includes taxes & fees

Oct 11 - Oct 12

A building with a sloped roof, a covered entrance, and a palm tree in the foreground.

A yellow building with multiple balconies and a green lawn.

A hotel room with a bed, a desk, a television, and a window with curtains.

A room with a patterned carpet, two potted plants, a wooden shelf with books, and a door with a sign.

17. Sunset Inn Manning I 95

Summerton

$54

$66 total

includes taxes & fees

Oct 21 - Oct 22

A spacious dining area with multiple tables and chairs, a reception desk, and large windows providing natural light.

A modern lobby with a wooden ceiling, a central seating area with a round table, and a bar with a variety of bottles.

A hotel room with two beds, a seating area, and a large abstract painting on the wall.

An outdoor patio area with a fire pit, seating, and tables.

18. SpringHill Suites by Marriott Orangeburg

Orangeburg

$109

$121 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with a bed, a black armchair, a round mirror with lights, a black vanity with a sink, and a white towel on the wall.

A modern room with a grey sofa, a small table, and a black countertop with a sink.

A building with a red roof and a covered entrance area. There are cars parked in front.

A bathroom with a textured wall, a round mirror with a light, a black countertop, and a white sink.

19. Starlight Stays

Manning

$68

$75 total

includes taxes & fees

Oct 8 - Oct 9

A reception desk with a flat-screen TV, a Dell computer, and a door.

A hotel room with two beds, a desk, a chair, and a wall-mounted lamp.

A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.

A hotel reception area with a counter, coffee machines, and a refrigerator.

20. Red Roof Inn Orangeburg

Orangeburg

$57

$63 total

includes taxes & fees

Oct 19 - Oct 20

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A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$129

per night

$143 total

includes taxes & fees

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$80

per night

$89 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$145

per night

$161 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

Holiday Inn Santee by IHG

Santee

$128

per night

$142 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

Best Western Plus Santee Inn

Santee

$154

per night

$171 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

Comfort Inn & Suites Santee

Santee

$129

per night

$143 total

includes taxes & fees

A spacious living area with a fireplace, two sofas, a coffee table, and ceiling fans.

A swimming pool with lounge chairs and a covered area, surrounded by buildings.

A building with a covered entrance, a lawn, and a curved driveway.

A hotel room with two beds, a TV, a desk, and a minibar.

Quality Inn & Suites Santee I-95

Santee

$64

per night

$76 total

includes taxes & fees

A motel with a brick facade, a covered entrance, and a satellite dish.

A two-story building with a yellow facade and a brick base, featuring a covered entrance and a visible mailbox.

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A compact living space with a dining area, kitchen, and a small entertainment setup.

Travelodge by Wyndham Santee

Santee

$69

per night

$77 total

includes taxes & fees

A two-story building with a beige facade, large windows, and a central entrance.

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A modern bathroom with a sink, toilet, and shower area.

Super 8 by Wyndham Santee/I-95

Santee

$75

per night

$83 total

includes taxes & fees

A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.

A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'

A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.

A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

Red Roof Inn Santee

Santee

$70

per night

$78 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

A building with a red roof, a yellow door, and a brick facade.

Econo Lodge Santee

Santee

$80

per night

$89 total

includes taxes & fees

Lobby

A gym with treadmills, an elliptical, dumbbells, and a bench.

A hotel room with two beds, a desk, and a chair.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$100

per night

$111 total

includes taxes & fees

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern hotel with a swimming pool, outdoor seating, and a covered patio area.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A hotel room with a large bed, a desk, a chair, a TV, and a window with a view of trees.

Fairfield Inn & Suites by Marriott Santee

Santee

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$80

per night

$89 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$131

per night

$145 total

includes taxes & fees

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

Fairfield Inn & Suites by Marriott Santee

Santee

$139

per night

$154 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

Holiday Inn Santee by IHG

Santee

$129

per night

$143 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$170

per night

$189 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

Best Western Plus Santee Inn

Santee

$155

per night

$172 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

Comfort Inn & Suites Santee

Santee

$130

per night

$144 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$64

per night

$76 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

A motel with a brick facade, a covered entrance, and a satellite dish.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

Travelodge by Wyndham Santee

Santee

$65

per night

$72 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A two-story building with a beige facade, large windows, and a central entrance.

Super 8 by Wyndham Santee/I-95

Santee

$8 off

$68

per night

$75 total

includes taxes & fees

A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.

A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'

A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.

A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

Red Roof Inn Santee

Santee

$70

per night

$78 total

includes taxes & fees

Lobby

A gym with treadmills, an elliptical, dumbbells, and a bench.

A hotel room with two beds, a desk, and a chair.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$91

per night

$101 total

includes taxes & fees

A hotel with a red roof and a covered outdoor area.

A building with a red roof, a yellow door, and a brick facade.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A reception area with a counter, framed pictures, and a clock on the wall.

Econo Lodge Santee

Santee

$80

per night

$89 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$135

per night

$299 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$130

per night

$289 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

Holiday Inn Santee by IHG

Santee

$134

per night

$296 total

includes taxes & fees

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

Fairfield Inn & Suites by Marriott Santee

Santee

$163

per night

$363 total

includes taxes & fees

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$100

per night

$222 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

Best Western Plus Santee Inn

Santee

$143

per night

$318 total

includes taxes & fees

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A pool area with a red umbrella, lounge chairs, and a green fence.

A Comfort Inn hotel with a parking lot and a building facade.

A hotel room with two single beds, a desk with a chair, a round mirror, and a flat-screen TV mounted on the wall.

Comfort Inn & Suites Santee

Santee

$141

per night

$314 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A two-story building with a beige facade, large windows, and a central entrance.

Super 8 by Wyndham Santee/I-95

Santee

$27 off

$77

per night

$170 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$67

per night

$158 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

A motel with a brick facade, a covered entrance, and a satellite dish.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

Travelodge by Wyndham Santee

Santee

$79

per night

$175 total

includes taxes & fees

A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.

A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'

A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.

A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

Red Roof Inn Santee

Santee

$72

per night

$160 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

A building with a red roof, a yellow door, and a brick facade.

Econo Lodge Santee

Santee

$79

per night

$176 total

includes taxes & fees

A modern kitchen with a central island, stainless steel appliances, and a large TV in the living area.

A compact kitchen with a dishwasher, a sink, and a black microwave.

A modern living room with a black sofa set, a small wooden table, and a kitchen area with a refrigerator and microwave.

A covered porch with wooden railings and two red chairs.

2 Mi to Lake Marion! Pet-friendly Home w/ Yard

Santee

$181

per night

$639 total

includes taxes & fees

Lobby

A gym with treadmills, an elliptical, dumbbells, and a bench.

A hotel room with two beds, a desk, and a chair.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$110

per night

$243 total

includes taxes & fees

Check out pet-friendly hotels in Santee

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

Fairfield Inn & Suites by Marriott Santee

Santee

$139

$154 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with a large bed, bedside lamps, a sofa, and a small table.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A Hampton Inn hotel with a modern facade, large windows, and a well-lit entrance.

A hotel room with a large bed, two bedside tables with lamps, a chair, and a desk.

Hampton Inn Santee-I-95

Santee

$110

$122 total

includes taxes & fees

Oct 18 - Oct 19

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

Best Western Plus Santee Inn

Santee

$131

$145 total

includes taxes & fees

Oct 14 - Oct 15

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$101

$112 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$80

$89 total

includes taxes & fees

Oct 8 - Oct 9

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

Holiday Inn Santee by IHG

Santee

$104

$115 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

A motel with a brick facade, a covered entrance, and a satellite dish.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Oct 11 - Oct 12

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$54

$65 total

includes taxes & fees

Oct 28 - Oct 29

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A two-story building with a beige facade, large windows, and a central entrance.

Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Oct 14 - Oct 15

A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.

A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'

A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.

A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Oct 11 - Oct 12

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You may also like hotels with pools in Santee

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

Fairfield Inn & Suites by Marriott Santee

Santee

$139

$154 total

includes taxes & fees

Oct 14 - Oct 15

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$110

$122 total

includes taxes & fees

Oct 18 - Oct 19

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

Best Western Plus Santee Inn

Santee

$131

$145 total

includes taxes & fees

Oct 14 - Oct 15

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$101

$112 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

Comfort Inn & Suites Santee

Santee

$103

$114 total

includes taxes & fees

Nov 1 - Nov 2

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

Holiday Inn Santee by IHG

Santee

$104

$115 total

includes taxes & fees

Oct 18 - Oct 19

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$54

$65 total

includes taxes & fees

Oct 28 - Oct 29

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A two-story building with a beige facade, large windows, and a central entrance.

Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Oct 14 - Oct 15

Lobby

A gym with treadmills, an elliptical, dumbbells, and a bench.

A hotel room with two beds, a desk, and a chair.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$88

$98 total

includes taxes & fees

Oct 13 - Oct 14

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Go beyond your typical stay in Santee

Pet friendly

Pool

Family friendly

Our prices for hotels in Santee are cheapest in November

Top landmarks in Santee

Santee State Park

8.0/10 (219 reviews)

Santee State Park is 2.7 mi (4.4 km) from central Santee, why not stop by during your stay.

Santee Cooper Country Club

7.8/10 (94 reviews)

You might want to play some rounds at Santee Cooper Country Club, located 0.6 mi (1 km) from central Santee. If Santee Cooper Country Club doesn't quite scratch your golfing itch, Santee National Golf Club is also nearby.

Santee National Golf Club

8.0/10 (74 reviews)

You might want to practice your swing at Santee National Golf Club, a golf course located 0.8 mi (1.4 km) from central Santee. If Santee National Golf Club doesn't quite scratch your golfing itch, Santee Cooper Country Club is also nearby.

Santee Town Hall

Santee Town Hall is worth a visit, located 1 mi (1.6 km) from central Santee.

Learn more about Santee

Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

See all hotels in Santee

A tree with Spanish moss and autumn leaves in a body of water.

Check out reviews of Santee hotels guests love

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good

"It was a good experience for a 1 night stay driving up from Florida. It is right off I-95, the price is good, nice and quiet and breakfast was good (waffles, bagels, yogurt, fruits, muffins and cereals). Thank you!!!"

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

10/10 Excellent

"Extremely good value for money, room was clean, tidy and very well appointed. Will absolutely come here again."

Super 8 by Wyndham, Orangeburg

Super 8 by Wyndham, Orangeburg

10/10 Excellent

"Clean.. Very friendly staff,, good breakfast. Air conditioning nice and Cool"

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

10/10 Excellent

"Everything"

Red Roof Inn Santee

Red Roof Inn Santee

10/10 Excellent

"Nice place. Clean & mattress was super comfy!"

Frequently asked questions

What accommodations do travelers like in Santee?

Guests like Tru By Hilton Santee, Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee.

Can I book refundable accommodations in Santee?

If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where should I stay in Santee if I'm looking for a reasonably priced accommodation?

A few inexpensive options worth considering are Tru By Hilton Santee, Baymont by Wyndham Santee and Comfort Inn & Suites Santee.

Where can I stay in Santee if I want a vacation rental instead of a hotel?

Browse 9 vacation homes on our site. You also might want to book one of 122 condos for your trip.

What will the weather in Santee be like during my vacation?

July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.

Why should I book my Santee hotel with Hotels.com?

There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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