Top 10 Hotels in Santee, SC in 2026 (from $57) | Hoteles.com

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Check prices for these dates

Tonight

Sep 17 - Sep 18

Tomorrow

Sep 18 - Sep 19

This weekend

Sep 18 - Sep 20

Next weekend

Sep 25 - Sep 27

Where to stay in Santee?

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

1. Tru By Hilton Santee

Santee

$98

$108 total

includes taxes & fees

Sep 27 - Sep 28

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A gym with treadmills, weight machines, and a wall of dumbbells.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

2. Hampton Inn Santee-I-95

Santee

$124

$138 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

3. Baymont by Wyndham Santee

Santee

$75

$83 total

includes taxes & fees

Sep 20 - Sep 21

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

4. Best Western Plus Santee Inn

Santee

$115

$127 total

includes taxes & fees

Sep 27 - Sep 28

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

5. Holiday Inn Santee by IHG

Santee

$110

$122 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

6. Comfort Inn & Suites Santee

Santee

$106

$118 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

7. Quality Inn & Suites Santee I-95

Santee

$58

$69 total

includes taxes & fees

Sep 24 - Sep 25

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A motel with a brick facade, a covered entrance, and a satellite dish.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

8. Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Sep 30 - Oct 1

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

9. Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Sep 23 - Sep 24

A church with a triangular roof, a central entrance, and a bell tower.

A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

10. Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A reception area with a counter, framed pictures, and a clock on the wall.

A bathroom with a sink, mirror, and a shower area.

11. Econo Lodge Santee

Santee

$65

$72 total

includes taxes & fees

Oct 12 - Oct 13

A gym with treadmills, an elliptical, dumbbells, and a bench.

A conference room with round tables, black chairs, and white tablecloths.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

12. Ramada by Wyndham Santee I-95

Santee

$71

$79 total

includes taxes & fees

Sep 23 - Sep 24

A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.

A hotel reception area with a counter, coffee machines, and a refrigerator.

A reception desk with a digital screen displaying 'Welcome' and 'Red Roof Inn.' There is a clock on the wall, a window with a view of a parking lot, and a refrigerator with 'Carolina's' branding.

A hotel room with a large bed, bedside tables, a desk, and a chair.

13. Red Roof Inn Orangeburg

Orangeburg

$58

$65 total

includes taxes & fees

Sep 24 - Sep 25

A hotel room with two beds, a desk, a chair, and a mirror.

A modern cafe with a stone backsplash, wooden cabinets, and yellow chairs.

A two-story building with a sign indicating it is a hotel.

A living room with a sofa, armchair, coffee table, and a flat-screen TV mounted on the wall.

14. SureStay Hotel by Best Western Manning

Manning

$82

$91 total

includes taxes & fees

Sep 30 - Oct 1

A self-service kiosk with a beverage cooler, microwave, and various food items.

A modern hotel lobby with a reception desk, blue and gray seating, a TV screen, and unique pendant lighting.

A modern interior with a dining area, seating arrangements, and a reception desk.

A breakfast counter with a sign reading 'TOP IT BREAKFAST,' a coffee machine, a yogurt dispenser, and various food items.

15. Tru by Hilton Orangeburg

Orangeburg

$114

$127 total

includes taxes & fees

Oct 1 - Oct 2

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A compact, modern room with a black and white striped wall, a built-in desk with a computer, and a small window.

A tent with two beds, a small table, and a chair.

A modern, two-story mobile home with a metal exterior, large windows, and a visible kitchen area.

16. Bells Marina & Resort

Eutawville

$82

$94 total

includes taxes & fees

Sep 20 - Sep 21

A two-story building with a sign reading "PachTree Inn".

A compact hotel room with a kitchenette, a television, a desk, and a chair.

A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.

A reception desk with a clock, framed certificates, and a window with a view.

17. Peach Tree Inn

St. George

$65

$70 total

includes taxes & fees

Oct 1 - Oct 2

A lobby with a reception desk, a sofa, a small round table, and an American flag.

A Holiday Inn Express & Suites building with a clear entrance, a covered waiting area, and a landscaped garden.

A modern hotel lobby with a reception desk, seating area, and a coffee bar.

A modern hotel lobby with a green ceiling, a grey sofa, a patterned ottoman, a wooden bench, and a chair with a geometric throw.

18. Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

$110

$122 total

includes taxes & fees

Sep 27 - Sep 28

A modern indoor pool area with a table and chairs, large windows, and a poolside lounge with sun loungers.

A modern indoor swimming pool with clear glass walls, sunlit lounge areas, and a view of greenery outside.

A lobby with a reception desk, a staircase, and seating area with orange chairs.

A modern kitchen with a wooden table and bench, blue cabinets, and a yellow pendant light fixture.

19. Spark by Hilton Orangeburg

Orangeburg

$98

$108 total

includes taxes & fees

Sep 20 - Sep 21

A bathroom with a large bathtub, a mirror, a sink, and a television.

A dining area with tables and chairs, a counter with food items, and a door.

A reception area with two grey armchairs, a wooden floor, and a painting of a tree-lined path on the wall.

A spacious lobby with a modern design, featuring a large sofa, a coffee table, and a television mounted on the wall.

20. Baymont by Wyndham Manning

Manning

$80

$89 total

includes taxes & fees

Sep 20 - Sep 21

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A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$75

per night

$83 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$135

per night

$150 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A motel with a brick facade, a covered entrance, and a satellite dish.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

Travelodge by Wyndham Santee

Santee

$65

per night

$72 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

Quality Inn & Suites Santee I-95

Santee

$64

per night

$77 total

includes taxes & fees

A church with a triangular roof, a central entrance, and a bell tower.

A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$70

per night

$78 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

Super 8 by Wyndham Santee/I-95

Santee

$75

per night

$83 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$192

per night

$213 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

Comfort Inn & Suites Santee

Santee

$161

per night

$179 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A reception area with a counter, framed pictures, and a clock on the wall.

A bathroom with a sink, mirror, and a shower area.

Econo Lodge Santee

Santee

$80

per night

$89 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

Holiday Inn Santee by IHG

Santee

$224

per night

$249 total

includes taxes & fees

A gym with treadmills, an elliptical, dumbbells, and a bench.

A conference room with round tables, black chairs, and white tablecloths.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$8 off

$75

per night

$83 total

includes taxes & fees

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$95

per night

$105 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A motel with a brick facade, a covered entrance, and a satellite dish.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

Travelodge by Wyndham Santee

Santee

$73

per night

$81 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

Quality Inn & Suites Santee I-95

Santee

$74

per night

$88 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$165

per night

$183 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A gym with treadmills, weight machines, and a wall of dumbbells.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$200

per night

$222 total

includes taxes & fees

A church with a triangular roof, a central entrance, and a bell tower.

A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$80

per night

$89 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

Super 8 by Wyndham Santee/I-95

Santee

$85

per night

$94 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$199

per night

$221 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

Comfort Inn & Suites Santee

Santee

$169

per night

$188 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

Holiday Inn Santee by IHG

Santee

$184

per night

$204 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A reception area with a counter, framed pictures, and a clock on the wall.

A bathroom with a sink, mirror, and a shower area.

Econo Lodge Santee

Santee

$84

per night

$94 total

includes taxes & fees

A gym with treadmills, an elliptical, dumbbells, and a bench.

A conference room with round tables, black chairs, and white tablecloths.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$10 off

$94

per night

$104 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A gym with treadmills, weight machines, and a wall of dumbbells.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$146

per night

$325 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$130

per night

$288 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

Holiday Inn Santee by IHG

Santee

$134

per night

$296 total

includes taxes & fees

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$100

per night

$222 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$140

per night

$311 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

Comfort Inn & Suites Santee

Santee

$135

per night

$299 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

Quality Inn & Suites Santee I-95

Santee

$67

per night

$159 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A motel with a brick facade, a covered entrance, and a satellite dish.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

Travelodge by Wyndham Santee

Santee

$71

per night

$158 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

Super 8 by Wyndham Santee/I-95

Santee

$77

per night

$170 total

includes taxes & fees

A church with a triangular roof, a central entrance, and a bell tower.

A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$72

per night

$160 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A reception area with a counter, framed pictures, and a clock on the wall.

A bathroom with a sink, mirror, and a shower area.

Econo Lodge Santee

Santee

$76

per night

$169 total

includes taxes & fees

A gym with treadmills, an elliptical, dumbbells, and a bench.

A conference room with round tables, black chairs, and white tablecloths.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$90

per night

$199 total

includes taxes & fees

Check out pet-friendly hotels in Santee

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$98

$108 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

$75

$83 total

includes taxes & fees

Sep 20 - Sep 21

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A gym with treadmills, weight machines, and a wall of dumbbells.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$124

$138 total

includes taxes & fees

Sep 27 - Sep 28

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$115

$127 total

includes taxes & fees

Sep 27 - Sep 28

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

Holiday Inn Santee by IHG

Santee

$110

$122 total

includes taxes & fees

Sep 20 - Sep 21

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A motel with a brick facade, a covered entrance, and a satellite dish.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Sep 30 - Oct 1

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

Quality Inn & Suites Santee I-95

Santee

$58

$69 total

includes taxes & fees

Sep 24 - Sep 25

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Sep 23 - Sep 24

A church with a triangular roof, a central entrance, and a bell tower.

A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Sep 20 - Sep 21

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You can also stay at hotels with a pool in Santee

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

$98

$108 total

includes taxes & fees

Sep 27 - Sep 28

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A gym with treadmills, weight machines, and a wall of dumbbells.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

$124

$138 total

includes taxes & fees

Sep 27 - Sep 28

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

Holiday Inn Santee by IHG

Santee

$110

$122 total

includes taxes & fees

Sep 20 - Sep 21

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

Quality Inn & Suites Santee I-95

Santee

$58

$69 total

includes taxes & fees

Sep 24 - Sep 25

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$115

$127 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

Comfort Inn & Suites Santee

Santee

$106

$118 total

includes taxes & fees

Sep 27 - Sep 28

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Sep 23 - Sep 24

A gym with treadmills, an elliptical, dumbbells, and a bench.

A conference room with round tables, black chairs, and white tablecloths.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$71

$79 total

includes taxes & fees

Sep 23 - Sep 24

View all properties

Go beyond your typical stay in Santee

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Our prices for hotels in Santee are cheapest in November

Top landmarks in Santee

Santee State Park

8.0/10 (219 reviews)

Santee State Park is 2.7 mi (4.4 km) from central Santee, why not stop by during your stay.

Santee Cooper Country Club

7.8/10 (94 reviews)

You might want to play some rounds at Santee Cooper Country Club, located 0.6 mi (1 km) from central Santee. If Santee Cooper Country Club doesn't quite scratch your golfing itch, Santee National Golf Club is also nearby.

Santee National Golf Club

8.0/10 (74 reviews)

You might want to practice your swing at Santee National Golf Club, a golf course located 0.8 mi (1.4 km) from central Santee. If Santee National Golf Club doesn't quite scratch your golfing itch, Santee Cooper Country Club is also nearby.

Santee Town Hall

Santee Town Hall is worth a visit, located 1 mi (1.6 km) from central Santee.

Learn more about Santee

Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

See all hotels in Santee

A tree with Spanish moss and autumn leaves in a body of water.

Check out reviews of Santee hotels guests love

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

A gym with treadmills, a bench, and a ball.

A snack shop with a sign reading "Hampton Suite Shop" and a variety of snacks and drinks on display.

A modern dining area with tables and chairs, large windows with sheer curtains, and pendant lighting.

Hampton Inn & Suites Orangeburg

Orangeburg

10/10 Exceptional

United States

Kevin

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

Holiday Inn Santee by IHG

Santee

10/10 Exceptional

United States

Catherine

A hotel lobby with a reception desk, seating area, and a large potted plant.

A hotel room with two beds, a TV, a desk, and a chair.

A hotel lobby with multiple seating areas, a reception desk, and a television.

A hotel lobby with seating areas, a television, and a patterned carpet.

Hampton Inn Manning

Manning

10/10 Exceptional

United States

Anonymous traveler

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A gym with treadmills, weight machines, and a wall of dumbbells.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

Hampton Inn Santee-I-95

Santee

10/10 Exceptional

United States

Michael

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A hotel room with two beds, a desk, and a large window with a view.

Tru By Hilton Santee

Santee

10/10 Exceptional

United States

Rebecca

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

10/10 Exceptional

United States

Richard

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

Baymont by Wyndham Santee

Santee

10/10 Exceptional

United States

Angel

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

Comfort Inn & Suites Santee

Santee

10/10 Exceptional

United States

Doug

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A motel with a brick facade, a covered entrance, and a satellite dish.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

Travelodge by Wyndham Santee

Santee

10/10 Exceptional

United States

Laurie

A hotel room with a bed, a desk, a chair, and a hanging coat rack.

A modern kitchen with a granite countertop, a built-in microwave, a sink, and a mirror above the counter.

A spacious living area with a wooden floor, a ceiling fan, a flat-screen TV, and a large window with sheer curtains.

A reception area with a stone wall, wooden reception desk, and a seating area with a TV and plants.

Suburban Studios Orangeburg

Orangeburg

10/10 Exceptional

United States

Wendy

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A compact, modern room with a black and white striped wall, a built-in desk with a computer, and a small window.

A tent with two beds, a small table, and a chair.

A modern, two-story mobile home with a metal exterior, large windows, and a visible kitchen area.

Bells Marina & Resort

Eutawville

10/10 Exceptional

United States

Jack

A hotel room with two beds, a desk, a chair, and a mirror.

A modern cafe with a stone backsplash, wooden cabinets, and yellow chairs.

A two-story building with a sign indicating it is a hotel.

A living room with a sofa, armchair, coffee table, and a flat-screen TV mounted on the wall.

SureStay Hotel by Best Western Manning

Manning

10/10 Exceptional

Coming off I-95 the property is on the left with a narrow entrance sandwiched between a Hampton Inn and a Wendy’s exit. I missed it the first time. I’m not sure whether this is a new property or an old motel that was renovated and rebranded as a Best Western hotel. In any case it is well maintained and attractive. It’s a couple of miles from downtown Manning so eating options are basically fast food. Breakfast buffet was OK. Good value.

United States

Anonymous traveler

A lobby with a reception desk, a sofa, a small round table, and an American flag.

A Holiday Inn Express & Suites building with a clear entrance, a covered waiting area, and a landscaped garden.

A modern hotel lobby with a reception desk, seating area, and a coffee bar.

A modern hotel lobby with a green ceiling, a grey sofa, a patterned ottoman, a wooden bench, and a chair with a geometric throw.

Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

10/10 Exceptional

United States

Deborah

A hotel room with two beds, a desk, and a chair. There are wall-mounted lamps and a large window with curtains.

A Comfort Inn & Suites hotel with a brick facade, multiple windows, and a clear blue sky.

A reception area with a wooden reception desk, a wall-mounted clock, and a welcome mat.

A restaurant with multiple tables and chairs, a wooden counter, and a painting on the wall.

Comfort Inn & Suites Orangeburg

Orangeburg

10/10 Exceptional

United States

Ken

A hotel room with two beds, a wooden desk, and a mirror.

A hotel lobby with a large sliding glass door, a reception desk, a seating area with red chairs, and a stone accent wall.

A Red Roof Inn lobby with a stone wall, red leather chairs, a sofa, a coffee station, and artwork on the walls.

A motel with a two-story structure, a covered entrance, and a parking lot.

Red Roof Inn St George, SC

St. George

10/10 Exceptional

The overall quality for this hotel was great. The interior was very up to date and it seemed clean for the most part. The only weird/inconvenient thing about this place is that check in was 3 and when we got to our room it still had not been cleaned but there was clean bedding thrown into a pile on the bed. So we just made the bed and put the full trash can from the previous stay outside of the door and the staff emptied it eventually. I would definitely stay here again and I recommend this...

United States

Anonymous traveler

Frequently Asked Questions

What accommodations do travelers like in Santee?

Guests like Tru By Hilton Santee, Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee.

Can I book refundable accommodations in Santee?

If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where should I stay in Santee if I'm looking for a reasonably priced accommodation?

A few inexpensive options worth considering are Tru By Hilton Santee, Baymont by Wyndham Santee and Comfort Inn & Suites Santee.

Where can I stay in Santee if I want a vacation rental instead of a hotel?

Browse 8 vacation homes on our site. You also might want to book one of 122 condos for your trip.

What will the weather in Santee be like during my vacation?

July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.

Why should I book my Santee hotel with Hotels.com?

There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.