Hotels in Santa Isabel

September 2026
11
October 2026

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Check prices for these dates

This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Where to stay in Santa Isabel?

1. Hotel del Norte

Hotel del Norte
Mexicali Historic Center
$53
$68 total
includes taxes & fees
Sep 14 - Sep 15
Hotel del Norte

2. Motel Virreyes

Motel Virreyes
Mexicali
$43
$49 total
includes taxes & fees
Sep 13 - Sep 14
Motel Virreyes

3. Hotel Lucerna Mexicali

Hotel Lucerna Mexicali
Mexicali
$106
$119 total
includes taxes & fees
Sep 12 - Sep 13
Hotel Lucerna Mexicali

4. City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali
Mexicali
$71
$80 total
includes taxes & fees
Sep 14 - Sep 15
City Express Plus by Marriott Mexicali

5. Holiday Inn Mexicali Centro Civico by IHG

Holiday Inn Mexicali Centro Civico by IHG
Civic Center
$97
$118 total
includes taxes & fees
Sep 18 - Sep 19
Holiday Inn Mexicali Centro Civico by IHG

6. Hotel Araiza Mexicali

Hotel Araiza Mexicali
Mexicali
$112
$126 total
includes taxes & fees
Sep 12 - Sep 13
Hotel Araiza Mexicali

7. One Mexicali

One Mexicali
Mexicali
$66
$75 total
includes taxes & fees
Sep 13 - Sep 14
One Mexicali

8. Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali
Mexicali
$110
$124 total
includes taxes & fees
Sep 18 - Sep 19
Fairfield Inn & Suites by Marriott Mexicali

9. Hotel Colonial Mexicali

Hotel Colonial Mexicali
Civic Center
$89
$100 total
includes taxes & fees
Sep 12 - Sep 13
Hotel Colonial Mexicali

10. City Express by Marriott Mexicali

City Express by Marriott Mexicali
Mexicali
$65
$74 total
includes taxes & fees
Oct 4 - Oct 5
City Express by Marriott Mexicali

11. Fiesta Inn Mexicali

Fiesta Inn Mexicali
Civic Center
$84
$95 total
includes taxes & fees
Sep 27 - Sep 28
Fiesta Inn Mexicali

12. Calafia Hotel

Calafia Hotel
Mexicali
$87
$98 total
includes taxes & fees
Sep 16 - Sep 17
Calafia Hotel

13. Hotel Cosmos Don Carlos

Hotel Cosmos Don Carlos
Mexicali
$50
$56 total
includes taxes & fees
Sep 17 - Sep 18
Hotel Cosmos Don Carlos

14. Sleep Inn Mexicali

Sleep Inn Mexicali
Mexicali
$70
$85 total
includes taxes & fees
Sep 13 - Sep 14
Sleep Inn Mexicali

15. Azteca de Oro Mexicali

Azteca de Oro Mexicali
Mexicali
$41
$46 total
includes taxes & fees
Sep 20 - Sep 21
Azteca de Oro Mexicali

16. Motel Diana

Motel Diana
Mexicali
$36
$42 total
includes taxes & fees
Sep 13 - Sep 14
Motel Diana

17. Holiday Inn Express & Suites Mexicali by IHG

Holiday Inn Express & Suites Mexicali by IHG
Mexicali
$135
$152 total
includes taxes & fees
Oct 11 - Oct 12
Holiday Inn Express & Suites Mexicali by IHG

18. Hotel Siesta Real

Hotel Siesta Real
Mexicali
$81
$91 total
includes taxes & fees
Sep 20 - Sep 21
Hotel Siesta Real

19. Hotel Boulevard Mexicali

Hotel Boulevard Mexicali
Mexicali
$42
$48 total
includes taxes & fees
Sep 17 - Sep 18
Hotel Boulevard Mexicali

20. Motel Las Fuentes

Motel Las Fuentes
Mexicali
$41
$50 total
includes taxes & fees
Sep 12 - Sep 13
Motel Las Fuentes
View all properties

Go beyond your typical stay in Santa Isabel

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
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Spa
Spa
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Family friendly
Family friendly
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Apart hotel
Apart hotel

Check out reviews of Santa Isabel hotels guests love

Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali
Mexicali

10/10 Exceptional

United States
Vicente
Courtyard by Marriott Mexicali

City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali
Mexicali

10/10 Exceptional

United States
Joan
City Express Plus by Marriott Mexicali

Motel Cies

Motel Cies
Mexicali

10/10 Exceptional

United States
Moyses
Motel Cies

City Express by Marriott Mexicali

City Express by Marriott Mexicali
Mexicali

10/10 Exceptional

United States
Alfonso
City Express by Marriott Mexicali

Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña
Mexicali

10/10 Exceptional

United States
Miguel Manzano
Extended Suites Mexicali Cataviña

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali
Mexicali

10/10 Exceptional

United States
MARIA DEL
Hotel Lucerna Mexicali

Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali
Mexicali

10/10 Exceptional

United States
Gabriel
Fairfield Inn & Suites by Marriott Mexicali

Hotel del Norte

Hotel del Norte
Mexicali Historic Center

10/10 Exceptional

United States
Elizabeth
Hotel del Norte

Motel Virreyes

Motel Virreyes
Mexicali

10/10 Exceptional

United States
Christina
Motel Virreyes

Hotel Araiza Mexicali

Hotel Araiza Mexicali
Mexicali

10/10 Exceptional

United States
Margarita
Hotel Araiza Mexicali

Calafia Hotel

Calafia Hotel
Mexicali

10/10 Exceptional

United States
ANGEL
Calafia Hotel

Motel Paraiso

Motel Paraiso
Mexicali

10/10 Exceptional

United States
Efrain
Motel Paraiso

Fiesta Inn Mexicali

Fiesta Inn Mexicali
Civic Center

10/10 Exceptional

United States
claudia
Fiesta Inn Mexicali

One Mexicali

One Mexicali
Mexicali

10/10 Exceptional

United States
Jesus
One Mexicali

Holiday Inn Mexicali Centro Civico by IHG

Holiday Inn Mexicali Centro Civico by IHG
Civic Center

10/10 Exceptional

United States
Gerardo
Holiday Inn Mexicali Centro Civico by IHG

Hotel Siesta Real

Hotel Siesta Real
Mexicali

10/10 Exceptional

United States
Heriberto
Hotel Siesta Real

Frequently Asked Questions

What hotels do travelers recommend in Santa Isabel?

Can I book a refundable hotel in Santa Isabel?

If you need the flexibility to change your plans to Santa Isabel, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Isabel be like during my trip?

July and August are typically the warmest months in Santa Isabel when the average temp is 93°F. December and January are the coldest months when the average temperature is 61°F. August and January are the months with the most rain.

Why should I book my Santa Isabel hotel through Hotels.com?

There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.