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Hotels in San Isidro

October 2026
November 2026

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Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Where to stay in San Isidro?

A waterfront property with a dock, a boat, and a building with a balcony.
A bedroom with a bed, a ceiling fan, a nightstand, and a bathroom visible through an open door.
A waterfront restaurant with outdoor seating, a dock, and a boat.
A bar area with a bartender, a computer monitor, and various bar tools.

1. Mamacita's Guest House

Mamacita's Guest House
Culebra Pueblo
$140
$168 total
includes taxes & fees
Sep 28 - Sep 29
Mamacita's Guest House
A covered outdoor dining area with wooden tables and chairs, overlooking a marina with sailboats.
A bedroom with a bed, a nightstand, a lamp, a window with a view of the sea, and a door leading to an outdoor balcony.
A coastal landscape with clear turquoise waters, a sandy beach, and a hill with a building.
A two-story building with a sign reading "El Navegante" and a staircase leading to the upper floor.

2. El Navegante de Culebra

El Navegante de Culebra
Culebra Pueblo
$170
$217 total
includes taxes & fees
Oct 12 - Oct 13
El Navegante de Culebra
A bedroom with a bed, a bedside table with a lamp, a window, and an air conditioning unit.
A beach with clear turquoise water, sandy shore, and green hills in the background.
A residential building named 'CASABLANC' with a gated entrance, a bench, and a pathway leading to the entrance.
A patio area with a table and chairs, a small garden, and a view of the surrounding neighborhood.

3. Turtle Nest

Turtle Nest
Culebra Pueblo
$109
$119 total
includes taxes & fees
Oct 16 - Oct 17
Turtle Nest
A bedroom with a large bed, a ceiling fan, and a balcony with a view of the sea.
A bathroom with two sinks, a large mirror, and a window with a scenic view of a sunset over water.
A pool area with a view of the ocean at sunset, surrounded by palm trees and a deck with seating.
A house with a view of the sea at sunset.

4. Las Quintas Reserve

Las Quintas Reserve
Culebra
$270
$374 total
includes taxes & fees
Oct 22 - Oct 23
Las Quintas Reserve
A beach with clear turquoise water, sandy shore, and palm trees.
A gated entrance with palm trees, a dirt path, and a view of the sea at sunset.
A bedroom with a bed, two bedside lamps, a ceiling fan, a television mounted on the wall, and a window with blinds.
A balcony with two chairs and a table, overlooking a coastal view with buildings and a clear sky.

5. Sea Gate Hotel

Sea Gate Hotel
Isabel II
$110
$126 total
includes taxes & fees
Sep 28 - Sep 29
Sea Gate Hotel
A clear blue pool with lounge chairs and palm trees.
A coastal view with a body of water, distant hills, and buildings with red-tiled roofs.
A kitchen with granite countertops, a stainless steel sink, and a built-in oven.
A person seated at a table with a plate of food, a glass of wine, and a bottle of Cuvée wine. The table is on an outdoor balcony with a view of a body of water and mountains in the background.

6. Costa Bonita Private Villa 604

Costa Bonita Private Villa 604
Culebra
$154
$335 total
includes taxes & fees
Oct 6 - Oct 7
Costa Bonita Private Villa 604
A deck with lounge chairs and colorful umbrellas overlooking a scenic view.
A clear pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a balcony.
A modern bathroom with a large mirror, dark wooden cabinets, a sink, and a towel rack.
A spacious room with a high ceiling, a bar area, and a large window offering a view of lush greenery.

7. Old Crow Hotel and Suites

Old Crow Hotel and Suites
Vieques
$99
$113 total
includes taxes & fees
Sep 28 - Sep 29
Old Crow Hotel and Suites
A room with a sofa, two chairs, a coffee table, and a large abstract painting on the wall.
A garden with several outdoor seating areas and a variety of tropical plants.
A hotel room with two beds, a green geometric wall design, a ceiling light, and a TV on the right.
A white multi-story building with multiple windows and air conditioning units, surrounded by lush greenery and a palm tree.

8. Vieques Tropical Guest House

Vieques Tropical Guest House
Isabel II
$51
$113 total
includes taxes & fees
Sep 28 - Sep 29
Vieques Tropical Guest House
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Go beyond your typical stay in San Isidro

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Pet friendly
Pet friendly
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Pool
Pool
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Apart­ment
Apart­ment
Family friendly image
Family friendly
Family friendly
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Villa
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Top landmarks in San Isidro

Playa Tortola

When the beach is calling your name, you might want to head down to Playa Tortola, located 0.8 mi (1.2 km) from central San Isidro. If you want to continue walking by the waves, head to Playa Cayo Norte located nearby.
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Playa Cayo Norte

Whether you want to collect beach glass or watch the sunset, Playa Cayo Norte is a spot you might want to check out, located 1.4 mi (2.3 km) from central San Isidro. If you want to continue walking by the waves, head to Playa Tortola located nearby.
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Check out reviews of San Isidro hotels guests love

A bedroom with a large bed, a ceiling fan, and a balcony with a view of the sea.
A bathroom with two sinks, a large mirror, and a window with a scenic view of a sunset over water.
A pool area with a view of the ocean at sunset, surrounded by palm trees and a deck with seating.
A house with a view of the sea at sunset.

Las Quintas Reserve

Las Quintas Reserve
Culebra

10/10 Exceptional

United States
April
Las Quintas Reserve
A beach with clear turquoise water, sandy shore, and palm trees.
A gated entrance with palm trees, a dirt path, and a view of the sea at sunset.
A bedroom with a bed, two bedside lamps, a ceiling fan, a television mounted on the wall, and a window with blinds.
A balcony with two chairs and a table, overlooking a coastal view with buildings and a clear sky.

Sea Gate Hotel

Sea Gate Hotel
Isabel II

10/10 Exceptional

United States
anup
Sea Gate Hotel
A covered outdoor dining area with wooden tables and chairs, overlooking a marina with sailboats.
A bedroom with a bed, a nightstand, a lamp, a window with a view of the sea, and a door leading to an outdoor balcony.
A coastal landscape with clear turquoise waters, a sandy beach, and a hill with a building.
A two-story building with a sign reading "El Navegante" and a staircase leading to the upper floor.

El Navegante de Culebra

El Navegante de Culebra
Culebra Pueblo

10/10 Exceptional

United States
Dana
El Navegante de Culebra
A waterfront property with a dock, a boat, and a building with a balcony.
A bedroom with a bed, a ceiling fan, a nightstand, and a bathroom visible through an open door.
A waterfront restaurant with outdoor seating, a dock, and a boat.
A bar area with a bartender, a computer monitor, and various bar tools.

Mamacita's Guest House

Mamacita's Guest House
Culebra Pueblo

10/10 Exceptional

United States
Mark
Mamacita's Guest House
A deck with lounge chairs and colorful umbrellas overlooking a scenic view.
A clear pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a balcony.
A modern bathroom with a large mirror, dark wooden cabinets, a sink, and a towel rack.
A spacious room with a high ceiling, a bar area, and a large window offering a view of lush greenery.

Old Crow Hotel and Suites

Old Crow Hotel and Suites
Vieques

10/10 Exceptional

United States
Viany
Old Crow Hotel and Suites
A room with a sofa, two chairs, a coffee table, and a large abstract painting on the wall.
A garden with several outdoor seating areas and a variety of tropical plants.
A hotel room with two beds, a green geometric wall design, a ceiling light, and a TV on the right.
A white multi-story building with multiple windows and air conditioning units, surrounded by lush greenery and a palm tree.

Vieques Tropical Guest House

Vieques Tropical Guest House
Isabel II

10/10 Exceptional

United States
Darrius
Vieques Tropical Guest House

Frequently Asked Questions

What hotels do travelers like in San Isidro?

Guests like Mamacita's Guest House, Club Seabourne Boutique Hotel and El Navegante de Culebra.

Can I book a refundable accommodation in San Isidro?

If you're looking for the flexibility to change your plans to San Isidro, most properties offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in San Isidro be like during my visit?

San Isidro is a great place to visit any time of year with an average temperature of 78°F during the coldest months.

Why should I book my San Isidro hotel through Hotels.com?

There are plenty of reasons to book your San Isidro travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.