Hotels in Prairie Home

October 2026
November 2026

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Where to stay in Prairie Home?

1. Baymont by Wyndham Columbia, MO

Baymont by Wyndham Columbia, MO
Columbia
$55
$62 total
includes taxes & fees
Sep 27 - Sep 28
Baymont by Wyndham Columbia, MO

2. Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination
Boonville
$76
$98 total
includes taxes & fees
Oct 20 - Oct 21
Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

3. Drury Inn & Suites Columbia Stadium Boulevard

Drury Inn & Suites Columbia Stadium Boulevard
Columbia
$100
$113 total
includes taxes & fees
Sep 27 - Sep 28
Drury Inn & Suites Columbia Stadium Boulevard

4. Tru By Hilton Columbia South

Tru By Hilton Columbia South
Columbia
$89
$102 total
includes taxes & fees
Sep 27 - Sep 28
Tru By Hilton Columbia South

5. Super 8 by Wyndham Boonville

Super 8 by Wyndham Boonville
Boonville
$67
$76 total
includes taxes & fees
Sep 29 - Sep 30
Super 8 by Wyndham Boonville

6. Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG
Columbia
$118
$134 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

7. Quality Inn & Suites Boonville - Columbia

Quality Inn & Suites Boonville - Columbia
Boonville
$94
$106 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn & Suites Boonville - Columbia

8. Hotel Blu

Hotel Blu
Columbia
$53
$59 total
includes taxes & fees
Sep 27 - Sep 28
Hotel Blu

9. Wyndham Executive Center Columbia

Wyndham Executive Center Columbia
Columbia
$121
$136 total
includes taxes & fees
Sep 27 - Sep 28
Wyndham Executive Center Columbia

10. Wingate by Wyndham - Columbia

Wingate by Wyndham - Columbia
Columbia
$86
$97 total
includes taxes & fees
Sep 27 - Sep 28
Wingate by Wyndham - Columbia

11. Midway Budget Inn

Midway Budget Inn
Columbia
$86
$91 total
includes taxes & fees
Sep 22 - Sep 23
Midway Budget Inn

12. Days Inn by Wyndham Boonville

Days Inn by Wyndham Boonville
Boonville
$42
$47 total
includes taxes & fees
Sep 23 - Sep 24
Days Inn by Wyndham Boonville

13. Stoney Creek Hotel Columbia

Stoney Creek Hotel Columbia
Columbia
$104
$117 total
includes taxes & fees
Sep 27 - Sep 28
Stoney Creek Hotel Columbia

14. Drury Plaza Hotel Columbia East

Drury Plaza Hotel Columbia East
Columbia
$102
$115 total
includes taxes & fees
Sep 27 - Sep 28
Drury Plaza Hotel Columbia East

15. Hampton Inn & Suites Columbia at University

Hampton Inn & Suites Columbia at University
Columbia
$102
$115 total
includes taxes & fees
Sep 27 - Sep 28
Hampton Inn & Suites Columbia at University

16. Holiday Inn Express Boonville by IHG

Holiday Inn Express Boonville by IHG
Boonville
$135
$173 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express Boonville by IHG

17. Best Western Plus Columbia Inn

Best Western Plus Columbia Inn
Columbia
$90
$102 total
includes taxes & fees
Sep 27 - Sep 28
Best Western Plus Columbia Inn

18. Country Inn & Suites by Radisson, Columbia, MO

Country Inn & Suites by Radisson, Columbia, MO
Columbia
$84
$95 total
includes taxes & fees
Oct 11 - Oct 12
Country Inn & Suites by Radisson, Columbia, MO

19. Comfort Suites Columbia - University Area

Comfort Suites Columbia - University Area
Columbia
$98
$111 total
includes taxes & fees
Sep 27 - Sep 28
Comfort Suites Columbia - University Area

20. Ramada by Wyndham Columbia

Ramada by Wyndham Columbia
Columbia
$60
$68 total
includes taxes & fees
Sep 29 - Sep 30
Ramada by Wyndham Columbia
View all properties

Go beyond your typical stay in Prairie Home

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
hot tub image
Hot tub
Hot tub
Family friendly image
Family friendly
Family friendly
Cottage image
Cottage
Cottage

Check out reviews of Prairie Home hotels guests love

Drury Inn & Suites Columbia Stadium Boulevard

Drury Inn & Suites Columbia Stadium Boulevard
Columbia

10/10 Exceptional

United States
Richard
Drury Inn & Suites Columbia Stadium Boulevard

Drury Plaza Hotel Columbia East

Drury Plaza Hotel Columbia East
Columbia

10/10 Exceptional

United States
Joshua
Drury Plaza Hotel Columbia East

Hotel Frederick

Hotel Frederick
Boonville

10/10 Exceptional

United States
Suzie B
Hotel Frederick

Baymont by Wyndham Columbia, MO

Baymont by Wyndham Columbia, MO
Columbia

10/10 Exceptional

United States
Donovan
Baymont by Wyndham Columbia, MO

Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG
Columbia

10/10 Exceptional

United States
Bvv
Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Iron Horse Hotel

Iron Horse Hotel
Blackwater

10/10 Exceptional

United States
Tina
Iron Horse Hotel

Wingate by Wyndham - Columbia

Wingate by Wyndham - Columbia
Columbia

10/10 Exceptional

United States
Barry
Wingate by Wyndham - Columbia

TownePlace Suites by Marriott Columbia

TownePlace Suites by Marriott Columbia
Columbia

10/10 Exceptional

United States
Anonymous traveler
TownePlace Suites by Marriott Columbia

Stoney Creek Hotel Columbia

Stoney Creek Hotel Columbia
Columbia

10/10 Exceptional

United States
Laura
Stoney Creek Hotel Columbia

Country Inn & Suites by Radisson, Columbia, MO

Country Inn & Suites by Radisson, Columbia, MO
Columbia

10/10 Exceptional

United States
Andrea
Country Inn & Suites by Radisson, Columbia, MO

Hampton Inn & Suites Columbia at University

Hampton Inn & Suites Columbia at University
Columbia

10/10 Exceptional

United States
Zzzzzzzzzzzzzz
Hampton Inn & Suites Columbia at University

The Broadway Columbia - a DoubleTree by Hilton

The Broadway Columbia - a DoubleTree by Hilton
Columbia

10/10 Exceptional

United States
Betty
The Broadway Columbia - a DoubleTree by Hilton

Wyndham Executive Center Columbia

Wyndham Executive Center Columbia
Columbia

10/10 Exceptional

United States
Melany
Wyndham Executive Center Columbia

Hampton Inn Columbia

Hampton Inn Columbia
Columbia

10/10 Exceptional

United States
Anonymous traveler
Hampton Inn Columbia

voco The Tiger Hotel Columbia, MO by IHG

voco The Tiger Hotel Columbia, MO by IHG
Columbia

10/10 Exceptional

United States
Anonymous traveler
voco The Tiger Hotel Columbia, MO by IHG

Frequently Asked Questions

Can I book a refundable hotel in Prairie Home?

If you want the flexibility to change your travel plans to Prairie Home, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Prairie Home be like during my trip?

The warmest months in Prairie Home are usually July and August with an average temp of 75°F. January and February are the chilliest months when the average temp is 36°F. The rainiest months are May and April.

Why should I book my Prairie Home hotel with Hotels.com?

There are plenty of reasons to book your Prairie Home travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.