Hotels in Clarksdale
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Quality Inn Cameron
Quality Inn Cameron
2.5 star property
Cameron
8.4 out of 10, Very Good, (624)
8.4/10
Very Good
(624)
The price is $92
$92
$103 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Holiday Inn Express Hotel & Suites St. Joseph by IHG
Holiday Inn Express Hotel & Suites St. Joseph by IHG
2.5 star property
St. Joseph
9.2 out of 10, Wonderful, (791)
9.2/10
Wonderful
(791)
The price is $101
$101
$117 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Fairfield Inn & Suites by Marriott St. Joseph
Fairfield Inn & Suites by Marriott St. Joseph
2.5 star property
St. Joseph
9.6 out of 10, Exceptional, (469)
9.6/10
Exceptional
(469)
The price is $114
$114
$133 total
includes taxes & fees
Dec 30 - Dec 31
Hampton Inn St. Joseph
Hampton Inn St. Joseph
2.5 star property
St. Joseph
8.2 out of 10, Very Good, (655)
8.2/10
Very Good
(655)
The price is $85
$85
$99 total
includes taxes & fees
Dec 29 - Dec 30
Red Roof Inn Cameron
Red Roof Inn Cameron
2.0 star property
Cameron
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $88
$88
$97 total
includes taxes & fees
Dec 31 - Jan 1, 2026
My Place Hotel St Joseph MO
My Place Hotel St Joseph MO
2.0 star property
St. Joseph
9.2 out of 10, Wonderful, (205)
9.2/10
Wonderful
(205)
The price is $80
$80
$93 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Home2 Suites By Hilton St. Joseph
Home2 Suites By Hilton St. Joseph
3.0 star property
St. Joseph
9.2 out of 10, Wonderful, (93)
9.2/10
Wonderful
(93)
The price is $106
$106
$122 total
includes taxes & fees
Dec 31 - Jan 1, 2026
SureStay Hotel by Best Western Cameron
SureStay Hotel by Best Western Cameron
2.5 star property
Cameron
8.2 out of 10, Very Good, (1000)
8.2/10
Very Good
(1000)
The price is $70
$70
$77 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Stoney Creek Hotel St. Joseph
Stoney Creek Hotel St. Joseph
3.5 star property
St. Joseph
9.0 out of 10, Wonderful, (1566)
9.0/10
Wonderful
(1566)
The price is $118
$118
$137 total
includes taxes & fees
Dec 26 - Dec 27
Days Inn by Wyndham Cameron
Days Inn by Wyndham Cameron
2.0 star property
Cameron
7.6 out of 10, Good, (828)
7.6/10
Good
(828)
The price is $66
$66
$73 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Capri Motel By OYO Elwood, Wathena
Capri Motel By OYO Elwood, Wathena
2.0 star property
Wathena
The price is $69
$69
$83 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Inn & Suites St Joseph
Drury Inn & Suites St Joseph
3.0 star property
St. Joseph
9.2 out of 10, Wonderful, (1000)
9.2/10
Wonderful
(1000)
The price is $100
$100
$116 total
includes taxes & fees
Dec 29 - Dec 30
Super 8 by Wyndham Cameron
Super 8 by Wyndham Cameron
2.0 star property
Cameron
8.4 out of 10, Very Good, (641)
8.4/10
Very Good
(641)
The price is $75
$75
$82 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Whiskey Mansion
Whiskey Mansion
2.5 star property
St. Joseph
9.2 out of 10, Wonderful, (586)
9.2/10
Wonderful
(586)
The price is $146
$146
$169 total
includes taxes & fees
Dec 26 - Dec 27
AmeriStay Inn
AmeriStay Inn
2.5 star property
St. Joseph
5.4 out of 10, (701)
5.4/10
(701)
The price is $84
$84
$97 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Vineyard Mansion & Carriage House Bed & Breakfast
Vineyard Mansion & Carriage House Bed & Breakfast
3.0 star property
St. Joseph
9.0 out of 10, Wonderful, (197)
9.0/10
Wonderful
(197)
The price is $107
$107
$157 total
includes taxes & fees
Dec 27 - Dec 28
Motel 6 Cameron, MO
Motel 6 Cameron, MO
2.0 star property
Cameron
7.0 out of 10, Good, (282)
7.0/10
Good
(282)
The price is $66
$66
$74 total
includes taxes & fees
Dec 26 - Dec 27
Econo Lodge Cameron
Econo Lodge Cameron
2.0 star property
Cameron
6.0 out of 10, (159)
6.0/10
(159)
The price is $68
$68
$75 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Cameron Suites
Cameron Suites
3.0 star property
Cameron
The price is $110
$110
$220 total
includes taxes & fees
Dec 26 - Dec 27
Motel 6 Saint Joseph, MO
Motel 6 Saint Joseph, MO
2.0 star property
St. Joseph
4.6 out of 10, (1000)
4.6/10
(1000)
The price is $63
$63
$73 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Clarksdale
Pet friendly
Family friendly
Check out reviews of Clarksdale hotels guests love
Days Inn by Wyndham Cameron
10/10 Excellent
"Parking lot was well lit and I was able to park in front of my room. Staff is always pleasant, helpful and friendly."
Holiday Inn Express Hotel & Suites St. Joseph by IHG
10/10 Excellent
"Very clean. "
Drury Inn & Suites St Joseph
10/10 Excellent
"Everything "
Stoney Creek Hotel St. Joseph
10/10 Excellent
"Shocked at how amazing it is for the price. My husband thought it would be so so and that he wouldnt really like it. The esthetics were awesome and cabin feel. I easily wouldve paid more."
Whiskey Mansion
10/10 Excellent
"Everything was perfect. Excellent place to stay.
Thanks.
Tom"
Fairfield Inn & Suites by Marriott St. Joseph
10/10 Excellent
"Everything here is good. The room was clean. They had excellent breakfast selection. Gym was good. Pool was cold but whatever. Staff is good. They have some beer and wine available as well. "
SureStay Hotel by Best Western Cameron
10/10 Excellent
"The room was clean staff was very friendly "
Red Roof Inn Cameron
10/10 Excellent
"Comfortable small hotel "
Hampton Inn St. Joseph
10/10 Excellent
"Was great overall"
Frequently asked questions
Can I book a refundable hotel in Clarksdale?
If you're looking for the flexibility to change your plans to Clarksdale, most accommodations offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Clarksdale be like during my visit?
The warmest months in Clarksdale are usually July and August with an average temp of 74°F. January and February are the chilliest months when the average temp is 33°F. The rainiest months are May and July.
Why should I book my Clarksdale hotel with Hotels.com?
There are plenty of reasons to book your Clarksdale travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.