Hotels in Byron

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Feb 4 - Feb 5
Tomorrow
Feb 5 - Feb 6
This weekend
Feb 6 - Feb 8
Next weekend
Feb 13 - Feb 15

Where to stay in Byron?

Property entrance
Country Inn & Suites Rochester South Mayo Clinic
Country Inn & Suites Rochester South Mayo Clinic
3.0 star property
Rochester
8.4 out of 10, Very Good, (1,008 reviews)
  • cleanliness
    A peaceful Mayo Clinic escape with complimentary hot breakfast and tranquil pool area.
The price is $87
$100 total
includes taxes & fees
Mar 1 - Mar 2
Country Inn & Suites Rochester South Mayo Clinic
Lobby
Comfort Inn & Suites Rochester South Mayo Clinic
Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,000 reviews)
  • cleanliness
    Stay minutes from Rochester airport with a rejuvenating pool and hot tub.
The price is $76
$87 total
includes taxes & fees
Mar 5 - Mar 6
Comfort Inn & Suites Rochester South Mayo Clinic
Front of property
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1,034 reviews)
  • cleanliness
    Convenient location near Mayo Clinic with free daily breakfast and on-site fitness.
The price is $72
$83 total
includes taxes & fees
Feb 6 - Feb 7
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Breakfast, lunch, dinner served; American cuisine
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (926 reviews)
  • cleanliness
    Relax in quiet comfort with Mayo Clinic just a 15-minute walk away from this hotel.
The price is $99
$114 total
includes taxes & fees
Feb 21 - Feb 22
Hotel Indigo Rochester – Mayo Clinic Area by IHG
View from property
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
2.5 star property
Kutzky Park
9.6 out of 10, Exceptional, (686 reviews)
  • cleanliness
    Stay moments from Mayo Clinic with shuttle service at this well-appointed hotel.
The price is $98
$113 total
includes taxes & fees
Feb 20 - Feb 21
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (813 reviews)
  • cleanliness
    Ideal hotel for Mayo Clinic visitors, with a convenient location and indoor pool.
The price is $94
$108 total
includes taxes & fees
Feb 8 - Feb 9
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Indoor pool, open 7:00 AM to 10:00 PM, sun loungers
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 star property
Downtown Rochester
8.0 out of 10, Very Good, (1,523 reviews)
  • cleanliness
    Mayo Clinic stay offers quiet retreat with convenient access to medical facilities.
The price is $132
$152 total
includes taxes & fees
Feb 5 - Feb 6
Kahler Inn and Suites - Mayo Clinic Area
Reception
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,003 reviews)
  • cleanliness
    Peaceful hotel near Mayo Clinic with indoor pool and daily complimentary breakfast.
The price is $81
$93 total
includes taxes & fees
Mar 6 - Mar 7
Hampton Inn Rochester-South
Reception
America's Stay Inn Stewartville
America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very Good, (424 reviews)
  • cleanliness
    Explore Mayo Clinic just 15 minutes away from this convenient Stewartville hotel.
The price is $58
$63 total
includes taxes & fees
Feb 9 - Feb 10
America's Stay Inn Stewartville
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (989 reviews)
  • cleanliness
    Located near Mayo Clinic with wellness-focused amenities and an indoor pool.
The price is $101
$118 total
includes taxes & fees
Feb 6 - Feb 7
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Terrace/patio
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,004 reviews)
  • cleanliness
    Stay near Mayo Clinic with comfort amenities and complimentary breakfast.
The price is $129
$149 total
includes taxes & fees
Feb 21 - Feb 22
Hyatt House Rochester/Mayo Clinic Area
Exterior
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park
9.2 out of 10, Wonderful, (781 reviews)
The price is $104
$120 total
includes taxes & fees
Feb 7 - Feb 8
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Exterior
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park
8.8 out of 10, Excellent, (774 reviews)
  • cleanliness
    Enjoy a tranquil stay near Mayo Clinic with indoor pool and complimentary perks.
The price is $103
$119 total
includes taxes & fees
Mar 1 - Mar 2
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Reception
Spark by Hilton Rochester South
Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (368 reviews)
  • cleanliness
    Cozy lodging near Mayo Clinic with complimentary breakfast and indoor pool access.
The price is $73
$84 total
includes taxes & fees
Feb 10 - Feb 11
Spark by Hilton Rochester South
Front of property
Aspen Suites
Aspen Suites
3.0 star property
Rochester
9.0 out of 10, Wonderful, (715 reviews)
  • cleanliness
    Make your Mayo Clinic stay hassle-free at this comfortable hotel with indoor pool.
The price is $145
$175 total
includes taxes & fees
Feb 8 - Feb 9
Aspen Suites
View from property
Kahler Grand Hotel
Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1,874 reviews)
  • cleanliness
    Quiet historic escape with indoor pool, minutes from Mayo Clinic facilities.
The price is $127
$146 total
includes taxes & fees
Feb 5 - Feb 6
Kahler Grand Hotel
Serves lunch, dinner, and happy hour
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very Good, (1,201 reviews)
  • cleanliness
    Peaceful retreat near Mayo Clinic with serene atmosphere and indoor pool.
The price is $74
$85 total
includes taxes & fees
Feb 15 - Feb 16
AmericInn by Wyndham Rochester Near Mayo Clinic
Restaurant
Hampton Inn & Suites Rochester-North
Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Modern Rochester hotel with Mayo Clinic access and revitalizing pool amenities.
The price is $89
$103 total
includes taxes & fees
Feb 15 - Feb 16
Hampton Inn & Suites Rochester-North
Lobby
Sleep Inn & Suites West-Near Medical Center
Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (604 reviews)
  • cleanliness
    Convenient hotel near Mayo Clinic with indoor pool and complimentary perks.
The price is $92
$106 total
includes taxes & fees
Feb 10 - Feb 11
Sleep Inn & Suites West-Near Medical Center
Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, free wired internet
Quality Inn near Medical Center
Quality Inn near Medical Center
2.5 star property
Rochester
7.8 out of 10, Good, (829 reviews)
  • cleanliness
    Convenient Mayo Clinic access with free breakfast, parking, and an indoor pool.
The price is $59
$68 total
includes taxes & fees
Feb 10 - Feb 11
Quality Inn near Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top landmarks in Byron

Putting Green

You might want to play some rounds at Putting Green, located 1.2 mi (1.9 km) from central Byron. If Putting Green doesn't quite scratch your golfing itch, Somerby Golf Club, and Links of Byron Mini Golf are also nearby.
See properties

Kalmar Town Hall

Kalmar Town Hall is worth a visit, located 2.9 mi (4.7 km) from central Byron.
See properties

Check out reviews of Byron hotels guests love

Hampton Inn Rochester-South

Hampton Inn Rochester-South

10/10 Excellent
"Very friendly staff always willing to help. Great breakfast area with evening soup which was wonderful on these cold January nights. Housekeeping did not come one time during our stay and the front desk was accommodating to give us extra towels and supplies we needed for our room."
Kathye 2-night trip
Posted 22 hours ago
Hampton Inn Rochester-South

Frequently asked questions

What hotels do travelers recommend in Byron?
Guests like Kahler Grand Hotel, AmericInn by Wyndham Rochester Near Mayo Clinic and Aspen Suites.
Can I book refundable accommodations in Byron?
If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Byron be like during my vacation?
July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.
Why should I book my Byron hotel with Hotels.com?
There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.