Hotels in Wapello

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Next weekend
In two weeks

Where to stay in Wapello?

Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn
2.5 star property
Mount Pleasant
8.2 out of 10, Very Good, (836 reviews)
Unwind at this tranquil hotel set in an open field where the indoor pool and poolside bar offer relaxation. Near Mt. Pleasant Station, the clean rooms include microwaves and fridges for added convenience.
The price is $73
$82 total
includes taxes & fees
Jun 22 - Jun 23
Best Western Mt. Pleasant Inn

AmericInn by Wyndham Muscatine

AmericInn by Wyndham Muscatine
3.0 star property
Muscatine
7.6 out of 10, Good, (453 reviews)
Soak in the hot tub after exploring nearby Muscatine Aquatic Center at this welcoming hotel. Enjoy free breakfast, WiFi, and parking, plus an indoor pool for year-round swimming. Business amenities and proximity to the municipal golf course make this spot versatile.
The price is $84
$94 total
includes taxes & fees
Jun 28 - Jun 29
AmericInn by Wyndham Muscatine

Super 8 by Wyndham Mt Pleasant

Super 8 by Wyndham Mt Pleasant
2.0 star property
Mount Pleasant
8.2 out of 10, Very Good, (854 reviews)
Escape to this tranquil hotel just a 3-minute drive from Mt. Pleasant Station. Wake up to complimentary breakfast, then explore nearby libraries. Enjoy free WiFi and parking while the attentive staff ensures a serene, clean retreat.
The price is $85
$95 total
includes taxes & fees
Jun 28 - Jun 29
Super 8 by Wyndham Mt Pleasant

Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant
2.5 star property
Mount Pleasant
8.2 out of 10, Very Good, (157 reviews)
Relax at this hotel with convenient train station access and complimentary amenities including daily buffet breakfast, WiFi and parking. The helpful staff receives consistent praise from travelers, while popular local attractions and libraries are just moments away.
The price is $74
$83 total
includes taxes & fees
Jul 12 - Jul 13
Quality Inn & Suites Mount Pleasant

The Sage Hotel

The Sage Hotel
2.0 star property
Muscatine
6.8 out of 10, (75 reviews)
Unwind at this welcoming hotel where free breakfast, WiFi, and parking enhance your stay. Located near Muscatine Aquatic Center and Geneva Golf and Country Club, this comfortable retreat offers convenience for exploring the area's popular spots.
The price is $65
$73 total
includes taxes & fees
Jul 1 - Jul 2
The Sage Hotel

Strawberry Farm Bed & Breakfast

Strawberry Farm Bed & Breakfast
3.0 star property
Muscatine
9.4 out of 10, Exceptional, (30 reviews)
Wake up to cooked-to-order breakfast at this charming Muscatine retreat. Enjoy hiking trails along the Mississippi River, then unwind in the garden or terrace. Free WiFi and parking make exploration easy, with Geneva Golf and Discovery Park nearby.
The price is $150
$168 total
includes taxes & fees
Jun 22 - Jun 23
Strawberry Farm Bed & Breakfast

Midtown Motel Burlington Near Hwy 34

Midtown Motel Burlington Near Hwy 34
Burlington
The price is $62
$73 total
includes taxes & fees
Jun 30 - Jul 1
Midtown Motel Burlington Near Hwy 34

Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
3.0 star property
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
Experience country charm in this cozy cottage with free parking and air conditioning. Located near the Horse and Buggy Museum and Dutton Lake, you're just a short drive from Burlington Station and Southeast Iowa Regional Airport.
The price is $122
$222 total
includes taxes & fees
Jun 22 - Jun 23
Idyllic Biggsville Vacation Rental: 10 Mi to River

Comfort Inn Muscatine near Hwy 61

Comfort Inn Muscatine near Hwy 61
2.5 star property
Muscatine
7.8 out of 10, Good, (237 reviews)
Located near Highway 61, this welcoming hotel offers free WiFi, buffet breakfast, and parking. Take a refreshing swim in the indoor pool after exploring nearby Muscatine Aquatic Center and Geneva Golf and Country Club. Just 42 minutes from Quad City International Airport.
The price is $81
$91 total
includes taxes & fees
Jul 12 - Jul 13
Comfort Inn Muscatine near Hwy 61

Holiday Inn Express Hotel & Suites Burlington by IHG

Holiday Inn Express Hotel & Suites Burlington by IHG
2.5 star property
Burlington
8.6 out of 10, Excellent, (509 reviews)
Just minutes from Catfish Bend Casino and FunCity, this Burlington hotel offers a refreshing indoor pool and complimentary morning meals. Enjoy free WiFi and parking after exploring nearby attractions or working out in the fitness center.
The price is $129
$149 total
includes taxes & fees
Jul 4 - Jul 5
Holiday Inn Express Hotel & Suites Burlington by IHG

Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel
2.5 star property
Muscatine
8.6 out of 10, Excellent, (526 reviews)
This riverside hotel offers an oasis of tranquility despite being in a busy area. Just 5 minutes from the Mississippi River, enjoy free breakfast before exploring nearby Muscatine Aquatic Center. The indoor pool provides year-round relaxation.
The price is $86
$96 total
includes taxes & fees
Jun 23 - Jun 24
Best Western Muscatine / Pearl City Hotel

AmericInn by Wyndham Mount Pleasant

AmericInn by Wyndham Mount Pleasant
3.0 star property
Mount Pleasant
8.6 out of 10, Excellent, (588 reviews)
Wake up to a delicious free breakfast at this convenient hotel with an indoor pool and fitness center. Located near Mt. Pleasant Station and local libraries, this quiet retreat offers free WiFi and parking with exceptionally helpful staff ready to assist.
The price is $85
$95 total
includes taxes & fees
Jun 28 - Jun 29
AmericInn by Wyndham Mount Pleasant

The Catfish Bend Inn & Spa

The Catfish Bend Inn & Spa
3.5 star property
Burlington
9.2 out of 10, Wonderful, (377 reviews)
Relaxation meets excitement at this hotel featuring 2 restaurants, 3 bars, and a full-service spa with massages. Near Catfish Bend Casino and FunCity, guests appreciate the helpful staff, outdoor pool, and free airport shuttle.
The price is $139
$160 total
includes taxes & fees
Jun 22 - Jun 23
The Catfish Bend Inn & Spa

Quality Inn Burlington near Hwy 34

Quality Inn Burlington near Hwy 34
2.5 star property
Burlington
7.4 out of 10, Good, (422 reviews)
This Quality Inn serves up a free breakfast buffet and offers convenient access to FunCity and Catfish Bend Casino. With complimentary WiFi and parking, plus attentive staff praised by fellow travelers, your Burlington entertainment getaway is hassle-free.
The price is $75
$84 total
includes taxes & fees
Jul 2 - Jul 3
Quality Inn Burlington near Hwy 34

Super 8 by Wyndham Muscatine

Super 8 by Wyndham Muscatine
2.0 star property
Muscatine
6.4 out of 10, (285 reviews)
This well-located Super 8 offers free Wi-Fi, parking, and daily on-the-go breakfast near Mississippi River. Just minutes from Muscatine Aquatic Center and Geneva Golf and Country Club, enjoy easy access to local attractions.
The price is $64
$71 total
includes taxes & fees
Jun 28 - Jun 29
Super 8 by Wyndham Muscatine

Evans Holly Grove Inn B&B

Evans Holly Grove Inn B&B
4.0 star property
Burlington
9.6 out of 10, Exceptional, (223 reviews)
The price is $155
$174 total
includes taxes & fees
Jun 23 - Jun 24
Evans Holly Grove Inn B&B

The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
4.0 star property
Muscatine
9.6 out of 10, Exceptional, (294 reviews)
Wake up to spectacular Mississippi River views at this Muscatine gem. Just steps from Riverside Park and the Muscatine Art Center, the hotel features an indoor pool, fitness center, and Maxwell's restaurant serving American cuisine throughout the day.
The price is $178
$199 total
includes taxes & fees
Jun 27 - Jun 28
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

Hampton Inn Muscatine

Hampton Inn Muscatine
2.5 star property
Muscatine
8.4 out of 10, Very Good, (484 reviews)
This modern hotel offers free daily buffet breakfast, WiFi, and parking. After exploring nearby attractions, recharge in the 24-hour fitness center. Conveniently located in Muscatine with easy access to Quad City International Airport, just 37 minutes away.
The price is $102
$114 total
includes taxes & fees
Jun 28 - Jun 29
Hampton Inn Muscatine

Fairfield Inn & Suites by Marriott Burlington

Fairfield Inn & Suites by Marriott Burlington
3.0 star property
Burlington
8.4 out of 10, Very Good, (309 reviews)
Wake to free breakfast at this business-friendly hotel before swimming in the indoor pool or heading to nearby Catfish Bend Casino. After exploring Burlington, return to your room, then grab a workout at the 24-hour fitness center.
The price is $127
$146 total
includes taxes & fees
Jul 16 - Jul 17
Fairfield Inn & Suites by Marriott Burlington

Hampton Inn & Suites Burlington

Hampton Inn & Suites Burlington
2.5 star property
Burlington
9.6 out of 10, Exceptional, (335 reviews)
The price is $123
$146 total
includes taxes & fees
Jun 28 - Jun 29
Hampton Inn & Suites Burlington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Wapello

The region around Wapello is home to attractions such as Mississippi River and Cairo Woods Wildlife Area.

The Mississippi River near Hannibal, Missouri, USA

Check out reviews of Wapello hotels guests love

Frequently asked questions

Can I book a refundable accommodation in Wapello?
If you want the flexibility to change your plans to Wapello, most properties offer refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Wapello be like during my trip?
July and August are typically the warmest months in Wapello when the average temp is 72°F. January and February are the coldest months when the average temperature is 30°F. June and May are the months with the most rain.
Why should I book my Wapello accommodation with Hotels.com?
There are lots of reasons to book your Wapello trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.