Hotels in O Brien

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Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (498 reviews)
  • cleanliness
    Relaxing retreat near Alachua Sports Complex with outdoor pool and fitness center.
The price is $106
$119 total
includes taxes & fees
Apr 19 - Apr 20
Hampton Inn & Suites Alachua I-75
Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
2.0 star property
Alachua
4.8 out of 10, (618 reviews)
  • cleanliness
    Kick back at this Alachua retreat with a refreshing outdoor pool and free parking.
The price is $73
$82 total
includes taxes & fees
Apr 18 - Apr 19
Americas Best Value Inn Alachua
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Walking distance to Alachua Sports Complex with outdoor pool, hot tub, and fitness center.
The price is $104
$117 total
includes taxes & fees
Apr 12 - Apr 13
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Vista Verde Farm Retreat
Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (17 reviews)
  • cleanliness
    Tranquil farm retreat near state parks with complimentary WiFi and parking.
The price is $113
$197 total
includes taxes & fees
Apr 12 - Apr 13
Vista Verde Farm Retreat
BlueGem Motel
BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (429 reviews)
  • cleanliness
    Explore High Springs from this centrally located motel with comfortable beds and helpful staff.
The price is $103
$116 total
includes taxes & fees
May 3 - May 4
BlueGem Motel
High Springs Country Inn
High Springs Country Inn
2.0 star property
High Springs
8.4 out of 10, Very Good, (26 reviews)
  • cleanliness
    Stay close to Civic Center Park with free WiFi at this convenient High Springs motel.
The price is $78
$88 total
includes taxes & fees
Apr 12 - Apr 13
High Springs Country Inn
Palms Garden Inn
Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (603 reviews)
  • cleanliness
    Comfortable motel with peaceful atmosphere and great staff near Lake City attractions.
The price is $65
$73 total
includes taxes & fees
Apr 12 - Apr 13
Palms Garden Inn
The Blanche
The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (179 reviews)
  • cleanliness
    Discover Lake City charm with free WiFi and premium bedding at this central hotel.
The price is $149
$167 total
includes taxes & fees
Apr 13 - Apr 14
The Blanche
Days Inn by Wyndham Lake City I-10
Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,002 reviews)
  • cleanliness
    Peaceful motel with a refreshing outdoor pool just minutes from Lake City attractions.
The price is $60
$68 total
includes taxes & fees
Apr 13 - Apr 14
Days Inn by Wyndham Lake City I-10
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (199 reviews)
  • cleanliness
    Experience tranquil escape at this riverside cabin with kitchenette and patio amenities.
The price is $110
$209 total
includes taxes & fees
Apr 20 - Apr 21
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (703 reviews)
  • cleanliness
    Cool Lake City getaway with free perks and outdoor pool near local attractions.
The price is $63
$71 total
includes taxes & fees
May 10 - May 11
Super 8 by Wyndham Lake City
Driftwood Inn
Driftwood Inn
2.0 star property
Lake City
7.8 out of 10, Good, (778 reviews)
  • cleanliness
    Explore Lake City from this modern hotel, with top attractions just minutes away.
The price is $60
$67 total
includes taxes & fees
Apr 12 - Apr 13
Driftwood Inn
Regal Inn
Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (576 reviews)
  • cleanliness
    Experience comfort just minutes away from Lake City attractions and dining options.
The price is $62
$70 total
includes taxes & fees
Apr 22 - Apr 23
Regal Inn
Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (232 reviews)
  • cleanliness
    Relax in spacious rooms at this Lake City hotel close to cinema and shopping.
The price is $105
$119 total
includes taxes & fees
Apr 19 - Apr 20
Courtyard By Marriott Lake City
Knights Inn Lake City
Knights Inn Lake City
1.5 star property
Lake City
5.4 out of 10, (648 reviews)
  • cleanliness
    Convenient Lake City stay with free WiFi and parking close to popular attractions.
The price is $55
$62 total
includes taxes & fees
Apr 10 - Apr 11
Knights Inn Lake City
Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Fitness-focused retreat with quick interstate access and helpful hotel staff.
The price is $105
$118 total
includes taxes & fees
Apr 12 - Apr 13
Holiday Inn & Suites Lake City by IHG
Quality Inn Lake City
Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very Good, (1,006 reviews)
  • cleanliness
    Unwind with a morning swim at this quiet Lake City hotel close to Regal Cinema.
The price is $72
$81 total
includes taxes & fees
May 10 - May 11
Quality Inn Lake City
La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.6 out of 10, Excellent, (1,088 reviews)
  • cleanliness
    Take a dip in this Lake City hotel's indoor pool at any hour of the day or night.
The price is $103
$115 total
includes taxes & fees
Apr 12 - Apr 13
La Quinta Inn & Suite by Wyndham Lake City
Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (999 reviews)
  • cleanliness
    Conveniently situated near I-75 with easy access to dining and shopping options.
The price is $63
$71 total
includes taxes & fees
Apr 12 - Apr 13
Days Inn by Wyndham Lake City I-75
Rodeway Inn Lake City I-75
Rodeway Inn Lake City I-75
2.0 star property
Lake City
6.8 out of 10, (393 reviews)
  • cleanliness
    Affordable lakeside stay with easy I-75 access and free breakfast each morning.
The price is $59
$66 total
includes taxes & fees
Apr 15 - Apr 16
Rodeway Inn Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about O Brien

O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Check out reviews of O Brien hotels guests love

Frequently asked questions

Can I book refundable hotels in O Brien?
If you want the flexibility to change your travel plans to O Brien, most accommodations provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in O Brien if I want a vacation home instead of a traditional hotel?
You'll find 6 vacation homes on our site.
What will the weather in O Brien be like during my vacation?
July and August are typically the warmest months in O Brien when the average temp is 80°F. January and February are the coldest months when the average temperature is 58°F. June and August are the months with the most rain.
Why should I book my O Brien hotel with Hotels.com?
There are lots of reasons to book your O Brien trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.