Hotels in San Sisto

October 2026
November 2026

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Check prices for these dates

Next weekend
Sep 25 - Sep 27
In two weeks
Oct 2 - Oct 4

Where to stay in San Sisto?

1. La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
Perugia
$95
$112 total
includes taxes & fees
Oct 4 - Oct 5
La Meridiana Bleisure Hotel

2. Relais dell'Olmo

Relais dell'Olmo
Perugia
$119
$130 total
includes taxes & fees
Oct 19 - Oct 20
Relais dell'Olmo

3. Hotel Perugia Plaza

Hotel Perugia Plaza
Perugia
$130
$150 total
includes taxes & fees
Sep 22 - Sep 23
Hotel Perugia Plaza

4. Best Western Hotel Quattrotorri Perugia

Best Western Hotel Quattrotorri Perugia
Perugia
$112
$130 total
includes taxes & fees
Sep 27 - Sep 28
Best Western Hotel Quattrotorri Perugia

5. Hotel Sacro Cuore

Hotel Sacro Cuore
Perugia
$82
$94 total
includes taxes & fees
Sep 23 - Sep 24
Hotel Sacro Cuore

6. Hotel Grifone

Hotel Grifone
Perugia
$103
$119 total
includes taxes & fees
Sep 24 - Sep 25
Hotel Grifone

7. Chocohotel

Chocohotel
Perugia
$129
$147 total
includes taxes & fees
Sep 30 - Oct 1
Chocohotel

8. Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
Perugia
$159
$183 total
includes taxes & fees
Oct 20 - Oct 21
Posta Donini 1579 UNA Esperienze

9. TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone
Perugia
$209
$238 total
includes taxes & fees
Sep 30 - Oct 1
TH Perugia - Castello di Monterone

10. Hotel Sant'Ercolano

Hotel Sant'Ercolano
Old Town Perugia
$82
$94 total
includes taxes & fees
Sep 22 - Sep 23
Hotel Sant'Ercolano

11. Primavera Mini Hotel

Primavera Mini Hotel
Old Town Perugia
$94
$109 total
includes taxes & fees
Sep 24 - Sep 25
Primavera Mini Hotel

12. Hotel Sangallo Palace

Hotel Sangallo Palace
Perugia
$150
$172 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Sangallo Palace

13. Locanda Stella

Locanda Stella
Perugia
$96
$110 total
includes taxes & fees
Sep 27 - Sep 28
Locanda Stella

14. Times Suites Guesthouse - Etruria Collection

Times Suites Guesthouse - Etruria Collection
Old Town Perugia
$111
$125 total
includes taxes & fees
Oct 13 - Oct 14
Times Suites Guesthouse - Etruria Collection

15. Locanda della Posta - Etruria Collection

Locanda della Posta - Etruria Collection
Old Town Perugia
$159
$182 total
includes taxes & fees
Sep 28 - Sep 29
Locanda della Posta - Etruria Collection

16. Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area
Perugia
$111
$129 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Giò Wine e Jazz Area

17. Hotel Priori Secret Garden

Hotel Priori Secret Garden
Old Town Perugia
$210
$237 total
includes taxes & fees
Oct 19 - Oct 20
Hotel Priori Secret Garden

18. Hotel Rosalba

Hotel Rosalba
Old Town Perugia
$67
$79 total
includes taxes & fees
Oct 7 - Oct 8
Hotel Rosalba

19. Residenza il Punto

Residenza il Punto
Perugia
$150
$169 total
includes taxes & fees
Sep 21 - Sep 22
Residenza il Punto

20. Relais La Corte Di Bettona

Relais La Corte Di Bettona
Bettona
$93
$102 total
includes taxes & fees
Sep 27 - Sep 28
Relais La Corte Di Bettona
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Go beyond your typical stay in San Sisto

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Apart hotel
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Waterpark
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Farm
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Top landmarks in San Sisto

Perugina Chocolate Factory

8.6/10 (58 reviews)
Perugina Chocolate Factory is 0.5 mi (0.9 km) from central San Sisto, why not stop by during your stay. If you have fun at Perugina Chocolate Factory, you'll love Citta della Domenica and Don Nello Palloni Centro Culturale, both located nearby.
See properties

Check out reviews of San Sisto hotels guests love

Relais dell'Olmo

Relais dell'Olmo
Perugia

10/10 Exceptional

United States
Anonymous traveler
Relais dell'Olmo

La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
Perugia

10/10 Exceptional

United States
Tahmina
La Meridiana Bleisure Hotel

Locanda Stella

Locanda Stella
Perugia

10/10 Exceptional

United States
Telma
Locanda Stella

TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone
Perugia

10/10 Exceptional

United States
Mark
TH Perugia - Castello di Monterone

Times Suites Guesthouse - Etruria Collection

Times Suites Guesthouse - Etruria Collection
Old Town Perugia

10/10 Exceptional

United States
Sally
Times Suites Guesthouse - Etruria Collection

Hotel Sacro Cuore

Hotel Sacro Cuore
Perugia

10/10 Exceptional

United States
Joseph
Hotel Sacro Cuore

Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
Perugia

10/10 Exceptional

United States
Anonymous traveler
Posta Donini 1579 UNA Esperienze

Hotel Perugia Plaza

Hotel Perugia Plaza
Perugia

10/10 Exceptional

United States
Jesmeet
Hotel Perugia Plaza

Locanda della Posta - Etruria Collection

Locanda della Posta - Etruria Collection
Old Town Perugia

10/10 Exceptional

United States
Pamela
Locanda della Posta - Etruria Collection

Chocohotel

Chocohotel
Perugia

10/10 Exceptional

United States
Julie
Chocohotel

Residenza il Punto

Residenza il Punto
Perugia

10/10 Exceptional

United States
Gina
Residenza il Punto

Primavera Mini Hotel

Primavera Mini Hotel
Old Town Perugia

10/10 Exceptional

United States
Anonymous traveler
Primavera Mini Hotel

Il Castellaro Country House

Il Castellaro Country House
Perugia

10/10 Exceptional

United States
Gregory
Il Castellaro Country House

Hotel Priori Secret Garden

Hotel Priori Secret Garden
Old Town Perugia

10/10 Exceptional

United States
Eric
Hotel Priori Secret Garden

The Bank Hotel - Etruria Collection

The Bank Hotel - Etruria Collection
Old Town Perugia

10/10 Exceptional

United States
Luis
The Bank Hotel - Etruria Collection

Hotel Sangallo Palace

Hotel Sangallo Palace
Perugia

10/10 Exceptional

United States
Nicole
Hotel Sangallo Palace

Deco Hotel

Deco Hotel
Perugia

10/10 Exceptional

United States
Nadia
Deco Hotel

Frequently Asked Questions

What hotels do travelers like in San Sisto?

Can I book refundable hotels in San Sisto?

If you want the flexibility to change your plans to San Sisto, most hotels provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in San Sisto be like during my vacation?

The warmest months in San Sisto are usually August and July with an average temp of 72°F. January and February are the chilliest months when the average temp is 44°F. The rainiest months are November and October.

Why should I book my San Sisto accommodation with Hotels.com?

There are plenty of reasons to book your San Sisto travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.