Hotels in Santo Tomé

October 2026
November 2026

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Next weekend
Sep 25 - Sep 27
In two weeks
Oct 2 - Oct 4

Where to stay in Santo Tomé?

1. Los Silos Hotel

Los Silos Hotel
Santa Fe
$132
$132 total
Oct 18 - Oct 19
Los Silos Hotel

2. InterTower Hotel

InterTower Hotel
Santa Fe
$119
$119 total
Oct 3 - Oct 4
InterTower Hotel

3. Castelar Hotel Santa Fe

Castelar Hotel Santa Fe
Santa Fe
$56
$56 total
Sep 27 - Sep 28
Castelar Hotel Santa Fe

4. Hotel Puerto Amarras

Hotel Puerto Amarras
Santa Fe
$109
$109 total
Oct 4 - Oct 5
Hotel Puerto Amarras

5. Maran Suites & Towers - Hotel & Spa

Maran Suites & Towers - Hotel & Spa
Parana
$120
$120 total
Sep 22 - Sep 23
Maran Suites & Towers - Hotel & Spa

6. Agustín 1 Apart

Agustín 1 Apart
Parana
$90
$90 total
Sep 21 - Sep 22
Agustín 1 Apart
View all properties

Go beyond your typical stay in Santo Tomé

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
spa image
Spa
Spa
Apartment image
Apart­ment
Apart­ment
Family friendly image
Family friendly
Family friendly

Top landmarks in Santo Tomé

El Museo Etnografico y Colonial Juan de Garay

If visiting museums in Santo Tomé are on your list, you might want to check out the upcoming exhibitions at El Museo Etnografico y Colonial Juan de Garay. If you want to see more of the museums in Santo Tomé, Historical Provincial Museum isn't far either.
See properties

Museo De Arte Contemporaneo

If visiting museums in Santo Tomé are on your list, you might want to check out the upcoming exhibitions at Museo De Arte Contemporaneo. If you want to see more of the museums in Santo Tomé, you can easily walk to El Museo Etnografico y Colonial Juan de Garay.
See properties

Learn more about Santo Tomé

Santo Tomé is well-known for its attractions such as El Museo Etnografico y Colonial Juan de Garay and Museo De Arte Contemporaneo.

See all hotels in Santo Tomé
A person holding a yerba mate cup with a snowy mountain range and a lake in the background.

Check out reviews of Santo Tomé hotels guests love

InterTower Hotel

InterTower Hotel
Santa Fe

10/10 Exceptional

United States
Jamin
InterTower Hotel

Castelar Hotel Santa Fe

Castelar Hotel Santa Fe
Santa Fe

10/10 Exceptional

United States
Joacir
Castelar Hotel Santa Fe

Maran Suites & Towers - Hotel & Spa

Maran Suites & Towers - Hotel & Spa
Parana

10/10 Exceptional

United States
Michael
Maran Suites & Towers - Hotel & Spa

Frequently Asked Questions

What accommodations do travelers like in Santo Tomé?

Can I book a refundable hotel in Santo Tomé?

If you want the flexibility to change your travel plans to Santo Tomé, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santo Tomé be like during my visit?

The warmest months in Santo Tomé are usually January and December with an average temp of 77°F. July and June are the chilliest months when the average temp is 57°F. The rainiest months are February and December.

Why should I book my Santo Tomé accommodation with Hotels.com?

There are plenty of reasons to book your Santo Tomé travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.